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The Journal of Neurophysiology Vol. 86 No. 4 October 2001, pp. 2041-2053
Copyright ©2001 by the American Physiological Society
Laboratory of Neurobiology, Hokkaido University School of Medicine, Sapporo 060-8638; and Core Research for Evolutional Science and Technology, Japan Science and Technology, Saitama 332-0012, Japan
Sawaguchi, Toshiyuki and
Michiyo Iba.
Prefrontal Cortical Representation of Visuospatial Working Memory
in Monkeys Examined by Local Inactivation With Muscimol. J. Neurophysiol. 86: 2041-2053, 2001. In
primates, dorsolateral areas of the prefrontal cortex (PFC) play a
major role in visuospatial working memory. To examine the functional
organization of the PFC for representing visuospatial working memory,
we produced reversible local inactivation, with the local injection of
muscimol (5 µg, 1 µl), at various sites (n = 100)
in the dorsolateral PFC of monkeys and observed the behavioral
consequences in an oculomotor delayed-response task that required
memory-guided saccades for locations throughout both visual fields. At
82 sites, the local injection of muscimol induced deficits in
memory-guided saccades to a few specific, usually contralateral, target
locations that varied with the location of the injection site. Such
deficits depended on the delay length, and longer delays were
associated with larger deficits in memory-guided saccades. The
injection sites and affected spatial locations of the target showed a
gross topographical relationship. No deficits appeared for a control
task in which the subject was required to make a visually guided
saccade to a visible target. These findings suggest that a specific
site in the dorsolateral PFC is responsible for the working memory
process for a specific visuospatial coordinate to guide goal-directed
behavior. Further, memoranda for specific visuospatial coordinates
appear to be represented in a topographical memory map
within the dorsolateral PFC to represent visuospatial working memory processes.
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