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The Journal of Neurophysiology Vol. 86 No. 5 November 2001, pp. 2276-2284
Copyright ©2001 by the American Physiological Society
1Department of Urology and 2Department of Pharmacology, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan
Mitsui, Takahiko,
Hidehiro Kakizaki,
Shinobu Matsuura,
Kaname Ameda,
Mitsuhiro Yoshioka, and
Tomohiko Koyanagi.
Afferent Fibers of the Hypogastric Nerves Are Involved in the
Facilitating Effects of Chemical Bladder Irritation in Rats. J. Neurophysiol. 86: 2276-2284, 2001. To
evaluate the role of bladder afferent fibers in the hypogastric nerves
(HGN) in modulation of the micturition reflex induced by chemical
bladder irritation, voiding behavior, continuous cystometry, and spinal
c-fos expression following intravesical acetic acid instillation were
investigated in rats with or without HGN transection. Voiding behavior
and continuous cystometry were examined in unanesthetized conscious
rats. Following chemical bladder irritation, a significant increase in
urinary frequency associated with a marked decrease in the voided
volume per micturition, was noted in control rats with the intact HGN,
but not in HGN-transected rats. Continuous infusion of acetic acid in
control rats elicited irritative bladder responses characterized by a
marked decrease in the intercontraction interval and a marked increase
in maximal vesical pressure, both of which were absent in
capsaicin-desensitized rats. HGN transection prevented the decrease in
the intercontraction interval but not an increase in maximal vesical
pressure following chemical bladder irritation. Compared with saline
infusion, acetic acid infusion caused a significant increase in c-fos
expression at L1 and L6 of the spinal cord, and
HGN transection significantly reduced c-fos expression in the dorsal
horn of the spinal cord at L1 but not at L6.
These results suggest that capsaicin-sensitive bladder afferent fibers
in the HGN, which travel through the rostral lumbar spinal cord, have a
role in urinary frequency caused by chemical bladder irritation.
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