JN Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 86: 2543-2558, 2001;
0022-3077/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (43)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Horwitz, G. D.
Right arrow Articles by Newsome, W. T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Horwitz, G. D.
Right arrow Articles by Newsome, W. T.

The Journal of Neurophysiology Vol. 86 No. 5 November 2001, pp. 2543-2558
Copyright ©2001 by the American Physiological Society

Target Selection for Saccadic Eye Movements: Prelude Activity in the Superior Colliculus During a Direction-Discrimination Task

Gregory D. Horwitz and William T. Newsome

Howard Hughes Medical Institute and Department of Neurobiology, Stanford University School of Medicine, Stanford, California 94305

Horwitz, Gregory D. and William T. Newsome. Target Selection for Saccadic Eye Movements: Prelude Activity in the Superior Colliculus During a Direction-Discrimination Task. J. Neurophysiol. 86: 2543-2558, 2001. We investigated the role of the superior colliculus (SC) in saccade target selection while macaque monkeys performed a direction-discrimination task. The monkeys selected one of two possible saccade targets based on the direction of motion in a stochastic random-dot display; the difficulty of the task was varied by adjusting the strength of the motion signal in the display. One of the two saccade targets was positioned within the movement field of the SC neuron under study while the other target was positioned well outside the movement field. Approximately 30% of the neurons in the intermediate and deep layers of the SC discharged target-specific preludes of activity that "predicted" target choices well before execution of the saccadic eye movement. Across the population of neurons, the strength of the motion signal in the display influenced the intensity of this "predictive" prelude activity: SC activity signaled the impending saccade more reliably when the motion signal was strong than when it was weak. The dependence of neural activity on motion strength could not be explained by small variations in the metrics of the saccadic eye movements. Predictive activity was particularly strong in a subpopulation of neurons with directional visual responses that we have described previously. For a subset of SC neurons, therefore, prelude activity reflects the difficulty of the direction discrimination in addition to the target of the impending saccade. These results are consistent with the notion that a restricted network of SC neurons plays a role in the process of saccade target selection.




This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
P. Liu and M. A. Basso
Substantia Nigra Stimulation Influences Monkey Superior Colliculus Neuronal Activity Bilaterally
J Neurophysiol, August 1, 2008; 100(2): 1098 - 1112.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
X. Li and M. A. Basso
Preparing to Move Increases the Sensitivity of Superior Colliculus Neurons
J. Neurosci., April 23, 2008; 28(17): 4561 - 4577.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
T. Ikeda and O. Hikosaka
Positive and Negative Modulation of Motor Response in Primate Superior Colliculus by Reward Expectation
J Neurophysiol, December 1, 2007; 98(6): 3163 - 3170.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. Ratcliff, Y. T. Hasegawa, R. P. Hasegawa, P. L. Smith, and M. A. Segraves
Dual Diffusion Model for Single-Cell Recording Data From the Superior Colliculus in a Brightness-Discrimination Task
J Neurophysiol, February 1, 2007; 97(2): 1756 - 1774.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. Campos, A. Cherian, and M. A. Segraves
Effects of Eye Position upon Activity of Neurons in Macaque Superior Colliculus
J Neurophysiol, January 1, 2006; 95(1): 505 - 526.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
X. Li and M. A. Basso
Competitive Stimulus Interactions within Single Response Fields of Superior Colliculus Neurons
J. Neurosci., December 7, 2005; 25(49): 11357 - 11373.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. C. Huk and M. N. Shadlen
Neural Activity in Macaque Parietal Cortex Reflects Temporal Integration of Visual Motion Signals during Perceptual Decision Making
J. Neurosci., November 9, 2005; 25(45): 10420 - 10436.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
G. Blohm, M. Missal, and P. Lefevre
Direct Evidence for a Position Input to the Smooth Pursuit System
J Neurophysiol, July 1, 2005; 94(1): 712 - 721.
[Abstract] [Full Text] [PDF]

Home page
 Neural Comput.Home page
V. Ventura
Testing for and Estimating Latency Effects for Poisson and Non-Poisson Spike Trains
Neural Comput., November 1, 2004; 16(11): 2323 - 2349.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. J. Krauzlis
Activity of Rostral Superior Colliculus Neurons During Passive and Active Viewing of Motion
J Neurophysiol, August 1, 2004; 92(2): 949 - 958.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
G. D. Horwitz, A. P. Batista, and W. T. Newsome
Representation of an Abstract Perceptual Decision in Macaque Superior Colliculus
J Neurophysiol, May 1, 2004; 91(5): 2281 - 2296.
[Abstract] [Full Text] [PDF]

Home page
 Neural Comput.Home page
M. C. Wiener
An Adjustment to the Time-Rescaling Method for Application to Short-Trial Spike Train Data
Neural Comput., November 1, 2003; 15(11): 2565 - 2576.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
M. E. Mazurek, J. D. Roitman, J. Ditterich, and M. N. Shadlen
A Role for Neural Integrators in Perceptual Decision Making
Cereb Cortex, November 1, 2003; 13(11): 1257 - 1269.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. Ratcliff, A. Cherian, and M. Segraves
A Comparison of Macaque Behavior and Superior Colliculus Neuronal Activity to Predictions From Models of Two-Choice Decisions
J Neurophysiol, September 1, 2003; 90(3): 1392 - 1407.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. R. Roesch and C. R. Olson
Impact of Expected Reward on Neuronal Activity in Prefrontal Cortex, Frontal and Supplementary Eye Fields and Premotor Cortex
J Neurophysiol, September 1, 2003; 90(3): 1766 - 1789.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. O. Helminski and M. A. Segraves
Macaque Frontal Eye Field Input to Saccade-Related Neurons in the Superior Colliculus
J Neurophysiol, August 1, 2003; 90(2): 1046 - 1062.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. M. McPeek, J. H. Han, and E. L. Keller
Competition Between Saccade Goals in the Superior Colliculus Produces Saccade Curvature
J Neurophysiol, May 1, 2003; 89(5): 2577 - 2590.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. I. Gold and M. N. Shadlen
The Influence of Behavioral Context on the Representation of a Perceptual Decision in Developing Oculomotor Commands
J. Neurosci., January 15, 2003; 23(2): 632 - 651.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. D. Roitman and M. N. Shadlen
Response of Neurons in the Lateral Intraparietal Area during a Combined Visual Discrimination Reaction Time Task
J. Neurosci., November 1, 2002; 22(21): 9475 - 9489.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. M. McPeek and E. L. Keller
Saccade Target Selection in the Superior Colliculus During a Visual Search Task
J Neurophysiol, October 1, 2002; 88(4): 2019 - 2034.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
G. D. Horwitz and W. T. Newsome
Target Selection for Saccadic Eye Movements: Direction-Selective Visual Responses in the Superior Colliculus
J Neurophysiol, November 1, 2001; 86(5): 2527 - 2542.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online