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The Journal of Neurophysiology Vol. 86 No. 5 November 2001, pp. 2571-2582
Copyright ©2001 by the American Physiological Society
División de Neurociencias, Laboratorio Andaluz de Biología, Universidad Pablo de Olavide, 41013 Seville, Spain
Múnera, A.,
A. Gruart,
M. D. Muñoz,
R. Fernández-Mas, and
J. M. Delgado-García.
Hippocampal Pyramidal Cell Activity Encodes Conditioned Stimulus
Predictive Value During Classical Conditioning in Alert Cats. J. Neurophysiol. 86: 2571-2582, 2001. We have recorded the firing activities of hippocampal pyramidal cells
throughout the classical conditioning of eyelid responses in alert
cats. Pyramidal cells (n = 220) were identified by
their antidromic activation from the ipsilateral fornix and according to their spike properties. Upper eyelid movements were recorded with
the search coil in a magnetic field technique. Latencies and firing
profiles of recorded pyramidal cells following the paired presentation
of conditioned (CS) and unconditioned (US) stimuli were similar,
regardless of the different sensory modalities used as CS (tones, air
puffs), the different conditioning paradigms (trace, delay), or the
different latency and topography of the evoked eyelid conditioned
responses. However, for the three paradigms used here, evoked neuronal
firing to CS presentation increased across conditioning, but remained
unchanged for US presentation. Contrarily, pyramidal cell firing was
not modified when the same stimuli used here as CS and US were
presented unpaired, during pseudoconditing sessions. Pyramidal cell
firing did not seem to encode eyelid position, velocity, or
acceleration for either reflex or conditioned eyelid responses. Evoked
pyramidal cell responses were always in coincidence with a beta
oscillatory activity in hippocampal extracellular field potentials. In
this regard, the beta rhythm represents a facilitation, or permissive
time window, for timed pyramidal cell firing. It is concluded that
pyramidal cells encode CS-US associative strength or CS predictive value.
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