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J Neurophysiol 86: 2966-2972, 2001;
0022-3077/01 $5.00
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The Journal of Neurophysiology Vol. 86 No. 6 December 2001, pp. 2966-2972
Copyright ©2001 by the American Physiological Society

Muscarine Reduces Calcium-Dependent Electrical Activity in Substantia Nigra Dopaminergic Neurons

Reese S. Scroggs,1 Carla G. Cardenas,1 Joseph A. Whittaker,2 and Stephen T. Kitai1

 1Department of Anatomy and Neurobiology, Health Science Center, University of Tennessee, Memphis, Tennessee 38163; and  2Morehouse School of Medicine, Neuroscience Institute, Atlanta, Georgia 30310

Scroggs, Reese S., Carla G. Cardenas, Joseph A. Whittaker, and Stephen T. Kitai. Muscarine Reduces Calcium-Dependent Electrical Activity in Substantia Nigra Dopaminergic Neurons. J. Neurophysiol. 86: 2966-2972, 2001. The effect of muscarine on Ca2+ dependent electrical activity was studied in dopamine (DA) neurons located in the substantia nigra pars compacta (SNc) in brain slices from young rats, using sharp electrodes. In most DA neurons tested, muscarine (50 µM) reduced the amplitude of spontaneous oscillatory potentials and evoked Ca2+-dependent potentials recorded in the presence of TTX. Muscarine also reduced the amplitude of the slow afterhyperpolarization (sAHP) following action potentials in most DA neurons. These data suggest that muscarine reduces Ca2+ entry in SNc DA neurons. The reduction of the amplitude of the sAHP by muscarine in DA neurons may facilitate bursting initiated by glutamatergic input by increasing the frequency at which DA neurons can fire. The reduction of the sAHP via activation of muscarinic receptors in vivo may provide a mechanism whereby cholinergic inputs to DA neurons from the tegmental peduncular pontine nucleus could modulate dopamine release at dopaminergic targets in the brain.




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