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J Neurophysiol 87: 351-360, 2002;
0022-3077/02 $5.00
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The Journal of Neurophysiology Vol. 87 No. 1 January 2002, pp. 351-360
Copyright ©2002 by the American Physiological Society

A2 Adenosine Receptors Inhibit Calcium Influx Through L-Type Calcium Channels in Rod Photoreceptors of the Salamander Retina

Salvatore L. Stella Jr., Eric J. Bryson, and Wallace B. Thoreson

Department of Pharmacology and Department of Ophthalmology, University of Nebraska Medical Center, Omaha, Nebraska 68198-5540

Stella Jr., Salvatore L., Eric J. Bryson, and Wallace B. Thoreson. A2 Adenosine Receptors Inhibit Calcium Influx Through L-Type Calcium Channels in Rod Photoreceptors of the Salamander Retina. J. Neurophysiol. 87: 351-360, 2002. Presynaptic inhibition is a major mechanism for regulating synaptic transmission in the CNS and adenosine inhibits Ca2+ currents (ICa) to reduce transmitter release at several synapses. Rod photoreceptors possess L-type Ca2+ channels that regulate the release of L-glutamate. In the retina, adenosine is released in the dark when L-glutamate release is maximal. We tested whether adenosine inhibits ICa and intracellular Ca2+ increases in rod photoreceptors in retinal slice and isolated cell preparations. Adenosine inhibited both ICa and the [Ca2+]i increase evoked by depolarization in a dose-dependent manner with ~25% inhibition at 50 µM. An A2-selective agonist, (N6-[2-(3,5-dimethoxyphenyl)-2-(2-methylphenyl)-ethyl]adenosine) (DPMA), but not the A1- or A3-selective agonists, (R)-N6-(1-methyl-2-phenylethyl)adenosine and N6-2-(4-aminophenyl)ethyladenosine, also inhibited ICa and depolarization-induced [Ca2+]i increases. An inhibitor of protein kinase A (PKA), Rp-cAMPS, blocked the effects of DPMA on both ICa and the depolarization-evoked [Ca2+]i increase in rods. The results suggest that activation of A2 receptors stimulates PKA to inhibit L-type Ca2+ channels in rods resulting in a decreased Ca2+ influx that should suppress glutamate release.




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