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J Neurophysiol 87: 508-515, 2002;
0022-3077/02 $5.00
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The Journal of Neurophysiology Vol. 87 No. 1 January 2002, pp. 508-515
Copyright ©2002 by the American Physiological Society

Reward-Dependent Spatial Selectivity of Anticipatory Activity in Monkey Caudate Neurons

Yoriko Takikawa, Reiko Kawagoe, and Okihide Hikosaka

Department of Physiology, Juntendo University School of Medicine, Tokyo 113-8421, Japan

Takikawa, Yoriko, Reiko Kawagoe, and Okihide Hikosaka. Reward-Dependent Spatial Selectivity of Anticipatory Activity in Monkey Caudate Neurons. J. Neurophysiol. 87: 508-515, 2002. Many neurons show anticipatory activity in learned tasks. This phenomenon appears to reflect the brain's ability to predict future events. However, what actually is predicted is unknown. Using a memory-guided saccade task, in which only one out of four directions was rewarded in each block of trials, we found that a group of neurons in the monkey caudate nucleus (CD) showed activity before presentation of an instruction cue stimulus. Among 329 CD neurons that were related to memory-guided saccade tasks, 156 showed the precue activity and 91 of them were examined fully. Remarkably, the magnitude of the precue activity varied across the four blocks of the one-direction-rewarded (1DR) condition, depending on which direction was rewarded. A majority of neurons with precue activity (83/91, 91%) showed significant directional preference. The best and worst directions were usually in the contralateral and ipsilateral directions, respectively. Within a block, the precue activity increased rapidly for the best direction in 1DR and decreased gradually for the worst direction in 1DR and all-directions-rewarded (ADR) condition. The precue activity was weak in ADR. The precue activity did not reflect the likelihood of a particular cue stimulus, because the probability of the cue appearing in each direction was the same regardless of the rewarded direction. These results suggest that each CD neuron indicates a particular position-reward association prospectively, usually with contralateral preference. Assuming that the CD neurons have access to saccadic motor outputs, the precue activity would create a motivational bias toward the contralateral space, even before an instruction is given by the cue stimulus.




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