| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Neurophysiology Vol. 87 No. 1 January 2002, pp. 567-588
Copyright ©2002 by the American Physiological Society
1Department of Cognitive Sciences, Graduate School of Human and Environmental Studies and 2Laboratory of Neurobiology, Faculty of Integrated Human Studies, Kyoto University, Kyoto 606-8501, Japan
Takeda, Kazuyoshi and
Shintaro Funahashi.
Prefrontal Task-Related Activity Representing Visual Cue Location
or Saccade Direction in Spatial Working Memory Tasks. J. Neurophysiol. 87: 567-588, 2002. To examine
what kind of information task-related activity encodes during spatial
working memory processes, we analyzed single-neuron activity in the
prefrontal cortex while two monkeys performed two different oculomotor
delayed-response (ODR) tasks. In the standard ODR task, monkeys were
required to make a saccade to the cue location after a 3-s delay,
whereas in the rotatory ODR (R-ODR) task, they were required to make a
saccade 90° clockwise from the cue location after the 3-s delay. By
comparing the same task-related activities in these two tasks, we could
determine whether such activities encoded the location of the visual
cue or the direction of the saccade. One hundred twenty one neurons exhibited task-related activity in relation to at least one task event
in both tasks. Among them, 41 neurons exhibited directional cue-period
activity, most of which encoded the location of the visual cue. Among
56 neurons with directional delay-period activity, 86% encoded the
location of the visual cue, whereas 13% encoded the direction of the
saccade. Among 57 neurons with directional response-period activity,
58% encoded the direction of the saccade, whereas 35% encoded the
location of the visual cue. Most neurons whose response-period activity
encoded the location of the visual cue also exhibited directional
delay-period activity that encoded the location of the visual cue as
well. The best directions of these two activities were identical, and
most of these response-period activities were postsaccadic. Therefore
this postsaccadic activity can be considered a signal to terminate
unnecessary delay-period activity. Population histograms encoding the
location of the visual cue showed tonic sustained activation during the
delay period. However, population histograms encoding the direction of
the saccade showed a gradual increase in activation during the delay
period. These results indicate that the transformation from visual
input to motor output occurs in the dorsolateral prefrontal cortex. The
analysis using population histograms suggests that this transformation occurs gradually during the delay period.
This article has been cited by other articles:
|
|
 |
|
  Y. Watanabe, K. Takeda, and S. Funahashi Population Vector Analysis of Primate Mediodorsal Thalamic Activity during Oculomotor Delayed-Response Performance Cereb Cortex, June 1, 2009; 19(6): 1313 - 1321. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Messinger, M. A. Lebedev, J. D. Kralik, and S. P. Wise Multitasking of Attention and Memory Functions in the Primate Prefrontal Cortex J. Neurosci., April 29, 2009; 29(17): 5640 - 5653. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Sakamoto, H. Mushiake, N. Saito, K. Aihara, M. Yano, and J. Tanji Discharge Synchrony during the Transition of Behavioral Goal Representations Encoded by Discharge Rates of Prefrontal Neurons Cereb Cortex, September 1, 2008; 18(9): 2036 - 2045. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Prime, M. Vesia, and J. D. Crawford Transcranial Magnetic Stimulation over Posterior Parietal Cortex Disrupts Transsaccadic Memory of Multiple Objects J. Neurosci., July 2, 2008; 28(27): 6938 - 6949. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Tanji and E. Hoshi Role of the Lateral Prefrontal Cortex in Executive Behavioral Control Physiol Rev, January 1, 2008; 88(1): 37 - 57. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Brozovic, A. Gail, and R. A. Andersen Gain Mechanisms for Contextually Guided Visuomotor Transformations J. Neurosci., September 26, 2007; 27(39): 10588 - 10596. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. R. Postle and M. Hamidi Nonvisual Codes and Nonvisual Brain Areas Support Visual Working Memory Cereb Cortex, September 1, 2007; 17(9): 2151 - 2162. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Carter and X.-J. Wang Cannabinoid-Mediated Disinhibition and Working Memory: Dynamical Interplay of Multiple Feedback Mechanisms in a Continuous Attractor Model of Prefrontal Cortex Cereb Cortex, September 1, 2007; 17(suppl_1): i16 - i26. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Watanabe and S. Funahashi Prefrontal Delay-Period Activity Reflects the Decision Process of a Saccade Direction during a Free-Choice ODR Task Cereb Cortex, September 1, 2007; 17(suppl_1): i88 - i100. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-D. Zhou, A. Ardestani, and J. M. Fuster Distributed and Associative Working Memory Cereb Cortex, September 1, 2007; 17(suppl_1): i77 - i87. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Okamoto, Y. Isomura, M. Takada, and T. Fukai Temporal Integration by Stochastic Recurrent Network Dynamics With Bimodal Neurons J Neurophysiol, June 1, 2007; 97(6): 3859 - 3867. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Procyk and P. S Goldman-Rakic Modulation of Dorsolateral Prefrontal Delay Activity during Self-Organized Behavior. J. Neurosci., November 1, 2006; 26(44): 11313 - 11323. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Genovesio, P. J. Brasted, and S. P. Wise Representation of future and previous spatial goals by separate neural populations in prefrontal cortex. J. Neurosci., July 5, 2006; 26(27): 7305 - 7316. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-i. Amemori and T. Sawaguchi Contrasting Effects of Reward Expectation on Sensory and Motor Memories in Primate Prefrontal Neurons Cereb Cortex, July 1, 2006; 16(7): 1002 - 1015. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. E. Curtis and M. D'Esposito Selection and Maintenance of Saccade Goals in the Human Frontal Eye Fields J Neurophysiol, June 1, 2006; 95(6): 3923 - 3927. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Genovesio, S. Tsujimoto, and S. P. Wise Neuronal Activity Related to Elapsed Time in Prefrontal Cortex J Neurophysiol, May 1, 2006; 95(5): 3281 - 3285. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. T. Baker, G. H. Patel, M. Corbetta, and L. H. Snyder Distribution of Activity Across the Monkey Cerebral Cortical Surface, Thalamus and Midbrain during Rapid, Visually Guided Saccades Cereb Cortex, April 1, 2006; 16(4): 447 - 459. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Inoue and A. Mikami Prefrontal Activity During Serial Probe Reproduction Task: Encoding, Mnemonic, and Retrieval Processes J Neurophysiol, February 1, 2006; 95(2): 1008 - 1041. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-C. Leung, J.C. Gore, and P.S. Goldman-Rakic Differential Anterior Prefrontal Activation during the Recognition Stage of a Spatial Working Memory Task Cereb Cortex, November 1, 2005; 15(11): 1742 - 1749. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Tsujimoto and T. Sawaguchi Context-dependent Representation of Response-outcome in Monkey Prefrontal Neurons Cereb Cortex, July 1, 2005; 15(7): 888 - 898. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Constantinidis and X.-J. Wang A Neural Circuit Basis for Spatial Working Memory Neuroscientist, December 1, 2004; 10(6): 553 - 565. [Abstract] [PDF]
|
|
|
|
|
|
K. Takeda and S. Funahashi Population Vector Analysis of Primate Prefrontal Activity during Spatial Working Memory Cereb Cortex, December 1, 2004; 14(12): 1328 - 1339. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Watanabe and S. Funahashi Neuronal Activity Throughout the Primate Mediodorsal Nucleus of the Thalamus During Oculomotor Delayed-Responses. I. Cue-, Delay-, and Response-Period Activity J Neurophysiol, September 1, 2004; 92(3): 1738 - 1755. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Watanabe and S. Funahashi Neuronal Activity Throughout the Primate Mediodorsal Nucleus of the Thalamus During Oculomotor Delayed-Responses. II. Activity Encoding Visual Versus Motor Signal J Neurophysiol, September 1, 2004; 92(3): 1756 - 1769. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. E. Curtis, V. Y. Rao, and M. D'Esposito Maintenance of Spatial and Motor Codes during Oculomotor Delayed Response Tasks J. Neurosci., April 21, 2004; 24(16): 3944 - 3952. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Amador, M. Schlag-Rey, and J. Schlag Primate Antisaccade. II. Supplementary Eye Field Neuronal Activity Predicts Correct Performance J Neurophysiol, April 1, 2004; 91(4): 1672 - 1689. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Fukushima, I. Hasegawa, and Y. Miyashita Prefrontal Neuronal Activity Encodes Spatial Target Representations Sequentially Updated After Nonspatial Target-Shift Cues J Neurophysiol, March 1, 2004; 91(3): 1367 - 1380. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Tsujimoto and T. Sawaguchi Neuronal Representation of Response-Outcome in the Primate Prefrontal Cortex Cereb Cortex, January 1, 2004; 14(1): 47 - 55. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Inoue, A. Mikami, I. Ando, and H. Tsukada Functional Brain Mapping of the Macaque Related to Spatial Working Memory as Revealed by PET Cereb Cortex, January 1, 2004; 14(1): 106 - 119. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
