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The Journal of Neurophysiology Vol. 87 No. 2 February 2002, pp. 669-678
Copyright ©2002 by the American Physiological Society
The Division of Life Sciences and The Cajal Neuroscience Research Center, The University of Texas, San Antonio, Texas 78249-0662
Do, Viet H.,
Carlo O. Martinez,
Joe L. Martinez Jr., and
Brian E. Derrick.
Long-Term Potentiation in Direct Perforant Path Projections
to the Hippocampal CA3 Region In Vivo. J. Neurophysiol. 87: 669-678, 2002. The perforant path constitutes
the primary projection system relaying information from the neocortex
to the hippocampal formation. Long-term synaptic potentiation (LTP) in
the perforant path projections to the dentate gyrus is well
characterized. However, surprisingly few studies have addressed the
mechanisms underlying LTP induction in the direct perforant path
projections to the hippocampus. Here we investigate the role of
N-methyl-D-aspartate (NMDA) and opioid receptors
in the induction of LTP in monosynaptic medial and lateral perforant
path projections to the CA3 region in adult pentobarbital sodium-anesthetized rats. Similar to LTP observed at the medial perforant path-dentate gyrus synapse, medial perforant path-CA3 synapses display LTP that is blocked by both local and systemic administration of the competitive NMDA receptor antagonist
(±)-3-(2-carboxypiperazin-4-yl) propyl-1-phosphonic acid [(±)-CPP].
By contrast, LTP induced at the lateral perforant path-CA3 synapses is
not blocked by either local or systemic administration of this NMDA
receptor antagonist. The induction of LTP at lateral perforant
path-CA3 synapses, which is blocked by the opioid receptor antagonist
naloxone, is also blocked by the selective mu (µ) opioid receptor
antagonist
Cys2-Tyr3-Orn5-Pen7-amide
(CTOP), but not the selective delta (
) opioid receptor antagonist
naltrindole (NTI). CTOP was without effect on the induction of medial
perforant path-CA3 LTP. The selective sensitivity of lateral perforant
path-CA3 LTP to µ-opioid receptor antagonists corresponds with the
distribution of µ-opioid receptors within the stratum
lacunosum-moleculare of area CA3 where perforant path projections to
CA3 terminate. These data indicate that both lateral and medial
perforant path projections to the CA3 region display LTP, and that LTP
induction in medial and lateral perforant path-CA3 synapses are
differentially sensitive to NMDA receptor and µ-opioid receptor
antagonists. This suggests a role for opioid, but not NMDA receptors in
the induction of LTP at lateral perforant path projections to the
hippocampal formation.
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