JN Add DOIs to your references at manuscript stage!
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 QUICK SEARCH:   [advanced]


     


J Neurophysiol 87: 1488-1498, 2002;
0022-3077/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (80)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kobayashi, S.
Right arrow Articles by Hikosaka, O.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kobayashi, S.
Right arrow Articles by Hikosaka, O.

The Journal of Neurophysiology Vol. 87 No. 3 March 2002, pp. 1488-1498
Copyright ©2002 by the American Physiological Society

Influence of Reward Expectation on Visuospatial Processing in Macaque Lateral Prefrontal Cortex

Shunsuke Kobayashi,1,2 Johan Lauwereyns,2 Masashi Koizumi,2 Masamichi Sakagami,2,3 and Okihide Hikosaka2

 1Department of Neurology, University of Tokyo School of Medicine, Tokyo 113-8655;  2Department of Physiology, Juntendo University School of Medicine, Tokyo 113-0033; and  3Brain Science Research Center, Tamagawa University Research Institute, Tokyo 194-8610, Japan

Kobayashi, Shunsuke, Johan Lauwereyns, Masashi Koizumi, Masamichi Sakagami, and Okihide Hikosaka. Influence of Reward Expectation on Visuospatial Processing in Macaque Lateral Prefrontal Cortex. J. Neurophysiol. 87: 1488-1498, 2002. The lateral prefrontal cortex (LPFC) has been implicated in visuospatial processing, especially when it is required to hold spatial information during a delay period. It has also been reported that the LPFC receives information about expected reward outcome. However, the interaction between visuospatial processing and reward processing is still unclear because the two types of processing could not be dissociated in conventional delayed response tasks. To examine this, we used a memory-guided saccade task with an asymmetric reward schedule and recorded 228 LPFC neurons. The position of the target cue indicated the spatial location for the following saccade and the color of the target cue indicated the reward outcome for a correct saccade. Activity of LPFC was classified into three main types: S-type activity carried only spatial signals, R-type activity carried only reward signals, and SR-type activity carried both. Therefore only SR-type cells were potentially involved in both visuospatial processing and reward processing. SR-type activity was enhanced (SR+) or depressed (SR-) by the reward expectation. The spatial discriminability as expressed by the transmitted information was improved by reward expectation in SR+ type. In contrast, when reward information was coded by an increase of activity in the reward-absent condition (SR- type), it did not improve the spatial representation. This activity appeared to be involved in gaze fixation. These results extend previous findings suggesting that the LPFC exerts dual influences based on predicted reward outcome: improvement of memory-guided saccades (when reward is expected) and suppression of inappropriate behavior (when reward is not expected).




This article has been cited by other articles:


Home page
J. Neurosci.Home page
H. Seo, D. J. Barraclough, and D. Lee
Lateral Intraparietal Cortex and Reinforcement Learning during a Mixed-Strategy Game
J. Neurosci., June 3, 2009; 29(22): 7278 - 7289.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
P. N. Tobler, G. I. Christopoulos, J. P. O'Doherty, R. J. Dolan, and W. Schultz
Risk-dependent reward value signal in human prefrontal cortex
PNAS, April 28, 2009; 106(17): 7185 - 7190.
[Abstract] [Full Text] [PDF]


Home page
J. Neurosci.Home page
K.-i. Okada, K. Toyama, Y. Inoue, T. Isa, and Y. Kobayashi
Different Pedunculopontine Tegmental Neurons Signal Predicted and Actual Task Rewards
J. Neurosci., April 15, 2009; 29(15): 4858 - 4870.
[Abstract] [Full Text] [PDF]


Home page
J. Neurosci.Home page
S. W. Kennerley and J. D. Wallis
Reward-Dependent Modulation of Working Memory in Lateral Prefrontal Cortex
J. Neurosci., March 11, 2009; 29(10): 3259 - 3270.
[Abstract] [Full Text] [PDF]


Home page
Phil Trans R Soc BHome page
H. Seo and D. Lee
Cortical mechanisms for reinforcement learning in competitive games
Phil Trans R Soc B, December 12, 2008; 363(1511): 3845 - 3857.
[Abstract] [Full Text] [PDF]


Home page
Cogn Affect Behav NeurosciHome page
P. N. Tobler, A. Kalis, and T. Kalenscher
The role of moral utility in decision making: An interdisciplinary framework
Cogn Affect Behav Neurosci, December 1, 2008; 8(4): 390 - 401.
[Abstract] [PDF]


Home page
J. Neurosci.Home page
P. N. Tobler, G. I. Christopoulos, J. P. O'Doherty, R. J. Dolan, and W. Schultz
Neuronal Distortions of Reward Probability without Choice
J. Neurosci., November 5, 2008; 28(45): 11703 - 11711.
[Abstract] [Full Text] [PDF]


Home page
Physiol. Rev.Home page
J. Tanji and E. Hoshi
Role of the Lateral Prefrontal Cortex in Executive Behavioral Control
Physiol Rev, January 1, 2008; 88(1): 37 - 57.
[Abstract] [Full Text] [PDF]


Home page
J. Neurosci.Home page
J.-W. Sohn and D. Lee
Order-Dependent Modulation of Directional Signals in the Supplementary and Presupplementary Motor Areas
J. Neurosci., December 12, 2007; 27(50): 13655 - 13666.
[Abstract] [Full Text] [PDF]


Home page
J. Neurophysiol.Home page
T. Ikeda and O. Hikosaka
Positive and Negative Modulation of Motor Response in Primate Superior Colliculus by Reward Expectation
J Neurophysiol, December 1, 2007; 98(6): 3163 - 3170.
[Abstract] [Full Text] [PDF]


Home page
Cereb CortexHome page
M. Watanabe and M. Sakagami
Integration of Cognitive and Motivational Context Information in the Primate Prefrontal Cortex
Cereb Cortex, September 1, 2007; 17(suppl_1): i101 - i109.
[Abstract] [Full Text] [PDF]


Home page
J. Neurosci.Home page
D. Lee, M. F. S. Rushworth, M. E. Walton, M. Watanabe, and M. Sakagami
Functional Specialization of the Primate Frontal Cortex during Decision Making
J. Neurosci., August 1, 2007; 27(31): 8170 - 8173.
[Abstract] [Full Text] [PDF]


Home page
J. Neurophysiol.Home page
L. Ding and O. Hikosaka
Temporal Development of Asymmetric Reward-Induced Bias in Macaques
J Neurophysiol, January 1, 2007; 97(1): 57 - 61.
[Abstract] [Full Text] [PDF]


Home page
J. Neurosci.Home page
E. Procyk and P. S Goldman-Rakic
Modulation of Dorsolateral Prefrontal Delay Activity during Self-Organized Behavior.
J. Neurosci., November 1, 2006; 26(44): 11313 - 11323.
[Abstract] [Full Text] [PDF]


Home page
Cereb CortexHome page
K.-i. Amemori and T. Sawaguchi
Contrasting Effects of Reward Expectation on Sensory and Motor Memories in Primate Prefrontal Neurons
Cereb Cortex, July 1, 2006; 16(7): 1002 - 1015.
[Abstract] [Full Text] [PDF]


Home page
J. Neurosci.Home page
L. Ding and O. Hikosaka
Comparison of reward modulation in the frontal eye field and caudate of the macaque.
J. Neurosci., June 21, 2006; 26(25): 6695 - 6703.
[Abstract] [Full Text] [PDF]


Home page
J. Neurosci.Home page
K. Nakamura and O. Hikosaka
Role of dopamine in the primate caudate nucleus in reward modulation of saccades.
J. Neurosci., May 17, 2006; 26(20): 5360 - 5369.
[Abstract] [Full Text] [PDF]


Home page
Cereb CortexHome page
J.-C. Dreher, P. Kohn, and K. F. Berman
Neural Coding of Distinct Statistical Properties of Reward Information in Humans
Cereb Cortex, April 1, 2006; 16(4): 561 - 573.
[Abstract] [Full Text] [PDF]


Home page
J. Neurophysiol.Home page
O. Hikosaka, K. Nakamura, and H. Nakahara
Basal Ganglia Orient Eyes to Reward
J Neurophysiol, February 1, 2006; 95(2): 567 - 584.
[Abstract] [Full Text] [PDF]


Home page
J. Neurophysiol.Home page
M. Inoue and A. Mikami
Prefrontal Activity During Serial Probe Reproduction Task: Encoding, Mnemonic, and Retrieval Processes
J Neurophysiol, February 1, 2006; 95(2): 1008 - 1041.
[Abstract] [Full Text] [PDF]


Home page
J. Neurophysiol.Home page
K. Watanabe and O. Hikosaka
Immediate Changes in Anticipatory Activity of Caudate Neurons Associated With Reversal of Position-Reward Contingency
J Neurophysiol, September 1, 2005; 94(3): 1879 - 1887.
[Abstract] [Full Text] [PDF]


Home page
J. Neurophysiol.Home page
M. Campos, B. Breznen, K. Bernheim, and R. A. Andersen
Supplementary Motor Area Encodes Reward Expectancy in Eye-Movement Tasks
J Neurophysiol, August 1, 2005; 94(2): 1325 - 1335.
[Abstract] [Full Text] [PDF]


Home page
J. Neurophysiol.Home page
M. R. Roesch and C. R. Olson
Neuronal Activity Dependent on Anticipated and Elapsed Delay in Macaque Prefrontal Cortex, Frontal and Supplementary Eye Fields, and Premotor Cortex
J Neurophysiol, August 1, 2005; 94(2): 1469 - 1497.
[Abstract] [Full Text] [PDF]


Home page
Cereb CortexHome page
S. Tsujimoto and T. Sawaguchi
Context-dependent Representation of Response-outcome in Monkey Prefrontal Neurons
Cereb Cortex, July 1, 2005; 15(7): 888 - 898.
[Abstract] [Full Text] [PDF]


Home page
J. Neurophysiol.Home page
S. Tsujimoto and T. Sawaguchi
Neuronal Activity Representing Temporal Prediction of Reward in the Primate Prefrontal Cortex
J Neurophysiol, June 1, 2005; 93(6): 3687 - 3692.
[Abstract] [Full Text] [PDF]


Home page
J. Neurophysiol.Home page
E. Hoshi and J. Tanji
Area-Selective Neuronal Activity in the Dorsolateral Prefrontal Cortex for Information Retrieval and Action Planning
J Neurophysiol, June 1, 2004; 91(6): 2707 - 2722.
[Abstract] [Full Text] [PDF]


Home page
J. Neurosci.Home page
D. Lee
Behavioral Context and Coherent Oscillations in the Supplementary Motor Area
J. Neurosci., May 5, 2004; 24(18): 4453 - 4459.
[Abstract] [Full Text] [PDF]


Home page
BrainHome page
R. J. Leigh and C. Kennard
Using saccades as a research tool in the clinical neurosciences
Brain, March 1, 2004; 127(3): 460 - 477.
[Abstract] [Full Text] [PDF]


Home page
Cereb CortexHome page
S. Tsujimoto and T. Sawaguchi
Neuronal Representation of Response-Outcome in the Primate Prefrontal Cortex
Cereb Cortex, January 1, 2004; 14(1): 47 - 55.
[Abstract] [Full Text] [PDF]


Home page
J. Neurosci.Home page
K. Watanabe, J. Lauwereyns, and O. Hikosaka
Neural Correlates of Rewarded and Unrewarded Eye Movements in the Primate Caudate Nucleus
J. Neurosci., November 5, 2003; 23(31): 10052 - 10057.
[Abstract] [Full Text] [PDF]


Home page
J. Neurophysiol.Home page
M. R. Roesch and C. R. Olson
Impact of Expected Reward on Neuronal Activity in Prefrontal Cortex, Frontal and Supplementary Eye Fields and Premotor Cortex
J Neurophysiol, September 1, 2003; 90(3): 1766 - 1789.
[Abstract] [Full Text] [PDF]


Home page
J. Neurophysiol.Home page
A. J. Gruber, S. A. Solla, D. J. Surmeier, and J. C. Houk
Modulation of Striatal Single Units by Expected Reward: A Spiny Neuron Model Displaying Dopamine-Induced Bistability
J Neurophysiol, August 1, 2003; 90(2): 1095 - 1114.
[Abstract] [Full Text] [PDF]


Home page
ScienceHome page
K. Matsumoto, W. Suzuki, and K. Tanaka
Neuronal Correlates of Goal-Based Motor Selection in the Prefrontal Cortex
Science, July 11, 2003; 301(5630): 229 - 232.
[Abstract] [Full Text] [PDF]


Home page
J. Neurosci.Home page
B. Coe, K. Tomihara, M. Matsuzawa, and O. Hikosaka
Visual and Anticipatory Bias in Three Cortical Eye Fields of the Monkey during an Adaptive Decision-Making Task
J. Neurosci., June 15, 2002; 22(12): 5081 - 5090.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online