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The Journal of Neurophysiology Vol. 87 No. 4 April 2002, pp. 1824-1835
Copyright ©2002 by the American Physiological Society
Department of Biomedical Engineering and Center for Hearing and Balance, Johns Hopkins University, Baltimore, Maryland 21205
Davis, Kevin A.
Evidence of a Functionally Segregated Pathway From Dorsal
Cochlear Nucleus to Inferior Colliculus. J. Neurophysiol. 87: 1824-1835, 2002. Type O units in the central
nucleus of the inferior colliculus (ICC) of decerebrate cats are
excited by best frequency (BF) tones near threshold, but are inhibited
by high-level tones at all frequencies. Dorsal cochlear nucleus (DCN)
principal cells display similar response map features and project
directly to the ICC, and are thus supposed to be the dominant source of
excitatory input for type O units. To test this hypothesis, the
responses of type O units were compared before and after two
pharmacological manipulations. When DCN to ICC axons were blocked by
pressure injections of lidocaine, most type O units (~80%) were
silenced or showed substantially reduced activity, but some units
showed increased activity. All of the former units had low maximal
rates to BF tones, whereas the latter units had high rates. When local circuit inhibitory mechanisms in the ICC were blocked by iontophoretic application of bicuculline or strychnine, type O unit responses also
fell into two classes: low-rate units that showed increased spontaneous
and driven activities and high-rate units that showed, in addition,
altered response map features. Taken together, these results
demonstrate that low-rate type O units are part of a functionally segregated pathway initiated by the DCN, whereas high-rate type O units
are created at the level of the ICC.
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