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The Journal of Neurophysiology Vol. 87 No. 4 April 2002, pp. 1981-1992
Copyright ©2002 by the American Physiological Society
Department of Anatomy and Neurobiology and Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland 21201
Cho, Young K.,
Cheng-Shu Li, and
David V. Smith.
Taste Responses of Neurons of the Hamster Solitary Nucleus Are
Enhanced by Lateral Hypothalamic Stimulation. J. Neurophysiol. 87: 1981-1992, 2002. Gustatory responses in the
brain stem are modifiable by several physiological factors, including
blood insulin and glucose, intraduodenal lipids, gastric distension,
and learning, although the neural substrates for these modulatory
effects are not known. Stimulation of the lateral hypothalamus (LH)
produces increases in food intake and alterations in taste preference
behavior, whereas damage to this area has opposite effects. In the
present study, we investigated the effects of LH stimulation on the
neural activity of taste-responsive cells in the nucleus of the
solitary tract (NST) of the hamster. Bipolar stimulating electrodes
were bilaterally implanted in the LH, and the responses of 99 neurons
in the NST, which were first characterized for their taste
sensitivities, were tested for their response to both ipsilateral and
contralateral LH stimulation. Half of the taste-responsive cells in the
NST (49/99) were modulated by LH stimulation. Contralateral stimulation was more often effective (41 cells) than ipsilateral (13 cells) and
always excitatory; 10 cells were excited bilaterally. Six cells were
inhibited by ipsilateral stimulation. A subset of these cells
(n = 13) was examined for the effects of microinjection of DL-homocysteic acid (DLH), a glutamate receptor agonist,
into the LH. The effects of electrical stimulation were completely mimicked by DLH, indicating that cell somata in and around the LH are
responsible for these effects. Other cells (n = 14)
were tested for the effects of electrical stimulation of the LH on the
responses to stimulation of the tongue with 0.032 M sucrose, NaCl, and
quinine hydrochloride, and 0.0032 M citric acid. Responses to taste
stimuli were more than doubled by the excitatory influence of the LH.
These data show that the LH, in addition to its role in feeding and
metabolism, exerts descending control over the processing of gustatory
information through the brain stem.
This article has been cited by other articles:
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  L. Mao, Y. K. Cho, and C.-S. Li Modulation of activity of gustatory neurons in the hamster parabrachial nuclei by electrical stimulation of the ventroposteromedial nucleus of the thalamus Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2008; 294(5): R1461 - R1473. [Abstract] [Full Text] [PDF]
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C.-S. Li, L. Mao, and Y. K. Cho Taste-responsive neurons in the nucleus of the solitary tract receive gustatory information from both sides of the tongue in the hamster Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2008; 294(2): R372 - R381. [Abstract] [Full Text] [PDF]
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C.-S. Li and Y. K. Cho Efferent projection from the bed nucleus of the stria terminalis suppresses activity of taste-responsive neurons in the hamster parabrachial nuclei. Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2006; 291(4): R914 - R926. [Abstract] [Full Text] [PDF]
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 A. C. Spector and S. P. Travers The representation of taste quality in the Mammalian nervous system. Behav Cogn Neurosci Rev, September 1, 2005; 4(3): 143 - 191. [Abstract] [PDF]
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 D. V. Smith, M.-K. Ye, and C.-S. Li Medullary Taste Responses are Modulated by the Bed Nucleus of the Stria Terminalis Chem Senses, June 1, 2005; 30(5): 421 - 434. [Abstract] [Full Text] [PDF]
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 N. Darcel, G. Fromentin, H. E. Raybould, S. Gougis, D. W. Gietzen, and D. Tome Fos-Positive Neurons Are Increased in the Nucleus of the Solitary Tract and Decreased in the Ventromedial Hypothalamus and Amygdala by a High-Protein Diet in Rats J. Nutr., June 1, 2005; 135(6): 1486 - 1490. [Abstract] [Full Text] [PDF]
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 C.-S. Li, Y. K. Cho, and D. V. Smith Modulation of Parabrachial Taste Neurons by Electrical and Chemical Stimulation of the Lateral Hypothalamus and Amygdala J Neurophysiol, March 1, 2005; 93(3): 1183 - 1196. [Abstract] [Full Text] [PDF]
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K. Tokita, Z. Karadi, T. Shimura, and T. Yamamoto Centrifugal Inputs Modulate Taste Aversion Learning Associated Parabrachial Neuronal Activities J Neurophysiol, July 1, 2004; 92(1): 265 - 279. [Abstract] [Full Text] [PDF]
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R. F. Lundy Jr. and R. Norgren Activity in the Hypothalamus, Amygdala, and Cortex Generates Bilateral and Convergent Modulation of Pontine Gustatory Neurons J Neurophysiol, March 1, 2004; 91(3): 1143 - 1157. [Abstract] [Full Text] [PDF]
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Y. K. Cho, C.-S. Li, and D. V. Smith Descending Influences from the Lateral Hypothalamus and Amygdala Converge onto Medullary Taste Neurons Chem Senses, February 1, 2003; 28(2): 155 - 171. [Abstract] [Full Text] [PDF]
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C.-S. Li, Y. K. Cho, and D. V. Smith Taste Responses of Neurons in the Hamster Solitary Nucleus Are Modulated by the Central Nucleus of the Amygdala J Neurophysiol, December 1, 2002; 88(6): 2979 - 2992. [Abstract] [Full Text] [PDF]
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