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The Journal of Neurophysiology Vol. 87 No. 4 April 2002, pp. 2009-2017
Copyright ©2002 by the American Physiological Society
1Department of Neurology, Yale University School of Medicine, New Haven 06510; 2Paralyzed Veterans of America/Eastern Paralyzed Veterans Association Neuroscience and Rehabilitation Research Center, Veterans Affairs Medical Center, West Haven, Connecticut 06516; and 3Department of Cell and Animal Biology, Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem 91904, Israel
Liu, Chang-Ning,
Marshall Devor,
Stephen G. Waxman, and
Jeffery D. Kocsis.
Subthreshold Oscillations Induced by Spinal Nerve Injury in
Dissociated Muscle and Cutaneous Afferents of Mouse DRG. J. Neurophysiol. 87: 2009-2017, 2002. Whole cell
patch-clamp recordings were obtained from dissociated mouse lumbar
dorsal root ganglion (DRG) neurons. Recordings were made from control
neurons and neurons axotomized by transection of the corresponding
spinal nerve 1
2 days prior to dissociation. Medium to large muscle
and cutaneous afferent neurons were identified by retrograde transport
of True Blue or Fluoro-Gold injected into the corresponding peripheral
tissue. Action potentials were classified as non-inflected spikes
(A0) and inflected spikes
(Ainf). High-frequency, low-amplitude
subthreshold membrane potential oscillations were observed in 8% of
control A0 neurons, but their incidence increased to 31% in the nerve injury group. Fifty percent of axotomized muscle
afferent A0 cells displayed oscillations, while
26% of axotomized cutaneous afferents exhibited oscillations.
Lower-frequency oscillations were also observed in a small fraction
(4%) of Ainf neurons on strong depolarization.
Their numbers were increased after the nerve injury, but the difference
was not statistically significant. The oscillations often triggered
burst firing in distinct patterns of action potential activity. These
results indicate that injury-induced membrane oscillations of DRG
neurons, previously observed in whole DRG of rats, are present in
dissociated DRG neurons of the adult mouse. Moreover, these
observations indicate that both muscle and cutaneous afferents in the
A
size range give rise to injury-induced
membrane oscillations, with muscle afferents being more prone to
develop oscillations.
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