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The Journal of Neurophysiology Vol. 87 No. 4 April 2002, pp. 2095-2103
Copyright ©2002 by the American Physiological Society
Nerve-Gut Research Laboratory, Department of Gastroenterology, Hepatology and General Medicine, Royal Adelaide Hospital, Adelaide, SA 5000; and Departments of Medicine and Physiology, University of Adelaide, SA 5005, Australia
Page, A. J.,
C. M. Martin, and
L. A. Blackshaw.
Vagal Mechanoreceptors and Chemoreceptors in Mouse Stomach
and Esophagus. J. Neurophysiol. 87: 2095-2103, 2002. We used a novel in vitro mouse
vagus-gastro-esophageal preparation to study the properties of
peripheral vagal afferent endings. We found two types of
mechanoreceptive fiber, mucosal receptors and tension receptors. These
were distinguished by their sensitivity to mucosal stroking with von
Frey hairs and circular tension applied via a claw-cantilever system. A
comparison was made with gastro-esophageal afferents found in a similar
preparation of ferret tissue. Responses of mouse tension receptors to
circular tension were significantly greater than ferret tension and
tension/mucosal receptors. Similarly the responses of mouse mucosal
receptors to mucosal stroking were significantly greater than ferret
mucosal and tension/mucosal receptors. Forty-seven percent of mouse
mucosal receptors and 50% of tension receptors responded to one or
more drugs or chemical stimuli applied to the receptive field. These
included 
,
-methylene ATP (10
6 to
103 M), 5-hydroxytryptamine
(106 to 103 M), and
hydrochloric acid (102 to
101 M). Drug responses were concentration
dependent. One hundred percent of mucosal receptors and 61% of tension
receptors tested responded to bile (1:8 to 1:1 dilution). A third type
of fiber was recruited by bile. These fibers were mechanically
insensitive and silent prior to bile exposure. In conclusion, we have
shown three types of gastro-esophageal vagal afferent fibers in the mouse: mucosal mechanoreceptors, tension receptors, and specific chemoreceptors activated by bile.
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