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The Journal of Neurophysiology Vol. 87 No. 4 April 2002, pp. 2190-2194
Copyright ©2002 by the American Physiological Society
RAPID COMMUNICATION
1Clinica Neurologica, Dipartimento di Neuroscienze, Università "Tor Vergata," Rome 00133; 2Fondazione Santa Lucia, Istituto di Ricovero e Cura a Carattere Scientifico, Rome 00179, Italy; and 3Department of Optometry and Neuroscience, UMIST, Manchester M60 1QD, United Kingdom
Bracci, Enrico,
Diego Centonze,
Giorgio Bernardi, and
Paolo Calabresi.
Dopamine Excites Fast-Spiking Interneurons in the Striatum. J. Neurophysiol. 87: 2190-2194, 2002. The
striatum is the main recipient of dopaminergic innervation. Striatal
projection neurons are controlled by cholinergic and GABAergic
interneurons. The effects of dopamine on projection neurons and
cholinergic interneurons have been described. Its action on GABAergic
interneurons, however, is still unknown. We studied the effects of
dopamine on fast-spiking (FS) GABAergic interneurons in vitro, with
intracellular recordings. Bath application of dopamine elicited a
depolarization accompanied by an increase in membrane input resistance
(an effect that persisted in the presence of tetrodotoxin) and
action-potential discharge. These effects were mimicked by the D1-like
dopamine receptor agonist SKF38393 but not by the D2-like agonist
quinpirole. Evoked corticostriatal glutamatergic synaptic currents were
not affected by dopamine. Conversely, GABAergic currents evoked by
intrastriatal stimulation were reversibly depressed by dopamine and
D2-like, but not D1-like, agonists. Cocaine elicited effects similar to
those of dopamine on membrane potential and synaptic currents. These
results show that endogenous dopamine exerts a dual excitatory action
on FS interneurons, by directly depolarizing them (through D1-like
receptors) and by reducing their synaptic inhibition (through
presynaptic D2-like receptors).
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