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J Neurophysiol 87: 2571-2576, 2002;
0022-3077/02 $5.00
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The Journal of Neurophysiology Vol. 87 No. 5 May 2002, pp. 2571-2576
Copyright ©2002 by the American Physiological Society

Inhibitory Interactions Between Ferret Thalamic Reticular Neurons

Yousheng Shu and David A. McCormick

Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510

Shu, Yousheng and David A. McCormick. Inhibitory Interactions Between Ferret Thalamic Reticular Neurons. J. Neurophysiol. 87: 2571-2576, 2002. The thalamic reticular nucleus (nRt) provides an important inhibitory input to thalamic relay nuclei and is central in the generation of both normal and abnormal thalamocortical activities. Although local inhibitory interactions between these neurons may play an important role in controlling thalamocortical activities, the physiological features of this interaction have not been fully investigated. Here we sought to establish the nature of inhibitory interaction between nRt neurons with intracellular and extracellular recordings in slices of ferret nRt maintained in vitro. In many nRt neurons, intracellular recordings revealed spontaneous inhibitory postsynaptic potentials (IPSPs). In addition, the local excitation of nRt cells with glutamate led to the generation of IPSPs in the intracellularly recorded nRt neuron. These evoked IPSPs exhibited an average reversal potential of -72 mV and could be blocked by picrotoxin, a GABAA-receptor antagonist. These results indicate that nRt neurons interact locally through the activation of GABAA receptor-mediated inhibitory postsynaptic potentials. This lateral inhibition may play an important role in controlling the responsiveness of these cells to cortical and thalamic excitatory inputs in both normal and abnormal thalamocortical function.




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