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The Journal of Neurophysiology Vol. 87 No. 6 June 2002, pp. 2904-2914
Copyright ©2002 by the American Physiological Society
Department of Cell Physiology, Max-Planck-Institute for Medical Research, Heidelberg D-69120, Germany
Petersen, Carl C. H.
Short-Term Dynamics of Synaptic Transmission Within the
Excitatory Neuronal Network of Rat Layer 4 Barrel Cortex. J. Neurophysiol. 87: 2904-2914, 2002. The short-term
plasticity of synaptic transmission between excitatory neurons within a
barrel of layer 4 rat somatosensory neocortex was investigated. Action
potentials in presynaptic neurons at frequencies ranging from 1 to 100 Hz evoked depressing postsynaptic excitatory postsynaptic potentials
(EPSPs). Recovery from synaptic depression followed an exponential time
course with best-fit parameters that differed greatly between
individual synaptic connections. The average maximal short-term
depression was close to 0.5 with a recovery time constant of around 500 ms. Analysis of each individual sweep showed that there was a
correlation between the amplitude of the response to the first and
second action potentials such that large first EPSPs were followed by
smaller than average second EPSPs and vice versa. Short-term depression
between excitatory layer 4 neurons can thus be termed use dependent. A
simple model describing use-dependent short-term plasticity was able to
closely simulate the experimentally observed dynamic behavior of these synapses for regular spike trains. More complex irregular trains of 10 action potentials occurring within 500 ms were initially well
described, but during the train errors increased. Thus for short
periods of time the dynamic behavior of these synapses can be predicted
accurately. In conjunction with data describing the connectivity, this
forms a first step toward computational modeling of the excitatory
neuronal network of layer 4 barrel cortex. Simulation of
whisking-evoked activity suggests that short-term depression may
provide a mechanism for enhancing the detection of objects within the
whisker space.
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