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J Neurophysiol 87: 3117-3125, 2002;
0022-3077/02 $5.00
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The Journal of Neurophysiology Vol. 87 No. 6 June 2002, pp. 3117-3125
Copyright ©2002 by the American Physiological Society

Properties of Nicotinic Receptors Underlying Renshaw Cell Excitation by alpha -Motor Neurons in Neonatal Rat Spinal Cord

Michelle Dourado and Peter B. Sargent

Departments of Stomatology and Physiology, University of California, San Francisco, California 94143

Dourado, Michelle and Peter B. Sargent. Properties of Nicotinic Receptors Underlying Renshaw Cell Excitation by alpha -Motor Neurons in Neonatal Rat Spinal Cord. J. Neurophysiol. 87: 3117-3125, 2002. We used anatomical and physiological approaches to characterize nicotinic receptors (AChRs) on Renshaw cells of the neonatal rat spinal cord. Confocal imaging of Renshaw cells, identified by their characteristic pattern of gephyrin immunoreactivity, revealed that these neurons are immuno-positive for the alpha 4 and beta 2 AChR subunits but not for the alpha 7 subunit. We used whole cell recording in spinal cord slices to characterize synaptic transmission from alpha -motor neurons to Renshaw cells, which could be identified pharmacologically by the sensitivity of transmission to d-tubocurarine. alpha -Motor neuron-to-Renshaw cell synapses were blocked by 10 µM dihydro-beta -erythroidine (dHbeta E), but not 50 nM methyllycaconitine (MLA), a selective alpha 7 antagonist. These findings support a role for alpha 4beta 2-like AChRs, but not alpha 7 AChRs, in rapid excitatory transmission between alpha -motor neurons and Renshaw cells in rat spinal cord.




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