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J Neurophysiol 87: 3156-3159, 2002;
0022-3077/02 $5.00
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The Journal of Neurophysiology Vol. 87 No. 6 June 2002, pp. 3156-3159
Copyright ©2002 by the American Physiological Society

RAPID COMMUNICATION

Optical Imaging of Odor Preference Memory in the Rat Olfactory Bulb

Qi Yuan,1,2 Carolyn W. Harley,3 John H. McLean,2 and Thomas Knöpfel1

 1Laboratory for Neuronal Circuit Dynamics, Brain Science Institute, The Institute of Physical and Chemical Research (RIKEN), Saitama 351-0198, Japan; and  2Division of Basic Medical Sciences and  3Department of Psychology, Memorial University of Newfoundland, St. John's, Newfoundland A1B 3V6, Canada

Yuan, Qi, Carolyn W. Harley, John H. McLean, and Thomas Knöpfel. Optical Imaging of Odor Preference Memory in the Rat Olfactory Bulb. J. Neurophysiol. 87: 3156-3159, 2002. Early olfactory preference learning in rat pups occurs when novel odors are paired with reinforcing tactile stimulation that activate the noradrenergic locus coeruleus. Pairing of odor and a noradrenergic agonist in the olfactory bulb is both necessary and sufficient for odor preference learning. This suggests the memory change occurs in the olfactory bulb. Previous electrophysiological experiments demonstrated that odor preference training induces an increase in the field excitatory postsynaptic potential to olfactory nerve input and an alteration, after training, in glomerular [14C]2- deoxyglucose uptake and in single-unit responses of principal cells. We investigate here whether, 24 h after olfactory preference training, there is an alteration in intrinsic optical signals at the glomerular level. Six-day-old rat pups were trained, as previously, for a peppermint odor preference. Trained pups and control littermates were subjected to imaging of odor-induced intrinsic optical signals 1 day after the training session. Trained pups exhibited significantly larger responses to the peppermint compared with untrained littermates previously exposed to the same odor. The response of trained pups to a control odor (amyl acetate) was, however, not significantly different from that of untrained littermates. These observations demonstrate that odor preference memory can be read-out by optical imaging techniques.




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