JN Watch the video to see how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 88: 2-12, 2002;
0022-3077/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (27)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Li, H.
Right arrow Articles by Prince, D. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Li, H.
Right arrow Articles by Prince, D. A.

The Journal of Neurophysiology Vol. 88 No. 1 July 2002, pp. 2-12
Copyright ©2002 by the American Physiological Society

Synaptic Activity in Chronically Injured, Epileptogenic Sensory-Motor Neocortex

Huifang Li and David A. Prince

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305

Li, Huifang and David A. Prince. Synaptic Activity in Chronically Injured, Epileptogenic Sensory-Motor Neocortex. J. Neurophysiol. 88: 2-12, 2002. We recorded spontaneous and evoked synaptic currents in pyramidal neurons of layer V in chronically injured, epileptogenic neocortex to assess changes in the efficacy of excitatory and inhibitory neurotransmission that might promote cortical hyperexcitability. Partial sensory-motor neocortical isolations with intact blood supply ("undercuts") were made in 20 rats on postnatal day 21-25 and examined 2-6 wk later in standard brain slice preparations using whole cell patch-clamp techniques. Age-matched, uninjured naive rats (n = 20) were used as controls. Spontaneous and miniature excitatory and inhibitory postsynaptic currents (s- and mEPSCs; s- and mIPSCs) were recorded using patch-clamp techniques. The average frequency of s- and mEPSCs was significantly higher, while that of s- and mIPSCs was significantly lower in neurons of undercuts versus controls. The increased frequency of excitatory events was due to an increase in both s- and mEPSC frequency, suggesting an increased number of excitatory contacts and/or increased release probability at excitatory terminals. No significant difference was observed in 10-90% rise time of these events. The input-output slopes of fast, short-latency, alpha -amino-3-hydroxy-5-methylisoxazole-4-propionic acid/kainate (AMPA/KA) receptor-mediated components of evoked EPSCs were steeper in undercuts than in controls. The peak amplitude of the AMPA/KA component of EPSCs evoked by supra-threshold stimuli was significantly greater in the partially isolated neocortex. In contrast, the N-methyl-D-aspartate receptor-mediated component of evoked EPSCs was not significantly different in neurons of injured versus control cortex, suggesting that the increased AMPA/KA component was due to postsynaptic alterations. Results support the conclusion that layer V pyramidal neurons receive increased AMPA/KA receptor-mediated excitatory synaptic drive and decreased GABAA receptor-mediated inhibition in this chronically injured, epileptogenic cortex. This shift in the balance of excitatory and inhibitory synaptic activation of layer V pyramidal cells toward excitation might be maladaptive and play a critical role in epileptogenesis.




This article has been cited by other articles:


Home page
 J. Neurosci.Home page
Y. David, L. P. Cacheaux, S. Ivens, E. Lapilover, U. Heinemann, D. Kaufer, and A. Friedman
Astrocytic Dysfunction in Epileptogenesis: Consequence of Altered Potassium and Glutamate Homeostasis?
J. Neurosci., August 26, 2009; 29(34): 10588 - 10599.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
C. A. Christian, J. Pielecka-Fortuna, and S. M. Moenter
Estradiol Suppresses Glutamatergic Transmission to Gonadotropin-Releasing Hormone Neurons in a Model of Negative Feedback in Mice
Biol Reprod, June 1, 2009; 80(6): 1128 - 1135.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. B. Ackman, L. Aniksztejn, V. Crepel, H. Becq, C. Pellegrino, C. Cardoso, Y. Ben-Ari, and A. Represa
Abnormal Network Activity in a Targeted Genetic Model of Human Double Cortex
J. Neurosci., January 14, 2009; 29(2): 313 - 327.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
D. A. Nita, Y. Cisse, I. Timofeev, and M. Steriade
Waking-Sleep Modulation of Paroxysmal Activities Induced by Partial Cortical Deafferentation
Cereb Cortex, February 1, 2007; 17(2): 272 - 283.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
S. Ivens, D. Kaufer, L. P Flores, I. Bechmann, D. Zumsteg, O. Tomkins, E. Seiffert, U. Heinemann, and A. Friedman
TGF-{beta} receptor-mediated albumin uptake into astrocytes is involved in neocortical epileptogenesis
Brain, February 1, 2007; 130(2): 535 - 547.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
X. Cai, D.-S. Wei, S. E. Gallagher, A. Bagal, Y.-A. Mei, J. P. Y. Kao, S. M. Thompson, and C.-M. Tang
Hyperexcitability of Distal Dendrites in Hippocampal Pyramidal Cells after Chronic Partial Deafferentation
J. Neurosci., January 3, 2007; 27(1): 59 - 68.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
L. Yang, L. S. Benardo, H. Valsamis, and D. S. F. Ling
Acute Injury to Superficial Cortex Leads to a Decrease in Synaptic Inhibition and Increase in Excitation in Neocortical Layer V Pyramidal Cells
J Neurophysiol, January 1, 2007; 97(1): 178 - 187.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
B. Halabisky, F. Shen, J. R. Huguenard, and D. A. Prince
Electrophysiological Classification of Somatostatin-Positive Interneurons in Mouse Sensorimotor Cortex
J Neurophysiol, August 1, 2006; 96(2): 834 - 845.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
X. Jin, D. A. Prince, and J. R. Huguenard
Enhanced excitatory synaptic connectivity in layer v pyramidal neurons of chronically injured epileptogenic neocortex in rats.
J. Neurosci., May 3, 2006; 26(18): 4891 - 4900.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
D. A. Nita, Y. Cisse, I. Timofeev, and M. Steriade
Increased Propensity to Seizures After Chronic Cortical Deafferentation In Vivo
J Neurophysiol, February 1, 2006; 95(2): 902 - 913.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
H. Karst and M. Joels
Corticosterone Slowly Enhances Miniature Excitatory Postsynaptic Current Amplitude in Mice CA1 Hippocampal Cells
J Neurophysiol, November 1, 2005; 94(5): 3479 - 3486.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
A. R. Houweling, M. Bazhenov, I. Timofeev, M. Steriade, and T. J. Sejnowski
Homeostatic Synaptic Plasticity Can Explain Post-traumatic Epileptogenesis in Chronically Isolated Neocortex
Cereb Cortex, June 1, 2005; 15(6): 834 - 845.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
X. Jin, J. R. Huguenard, and D. A. Prince
Impaired Cl- Extrusion in Layer V Pyramidal Neurons of Chronically Injured Epileptogenic Neocortex
J Neurophysiol, April 1, 2005; 93(4): 2117 - 2126.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
K. M. Jacobs and D. A. Prince
Excitatory and Inhibitory Postsynaptic Currents in a Rat Model of Epileptogenic Microgyria
J Neurophysiol, February 1, 2005; 93(2): 687 - 696.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
H. Li, A. E. Bandrowski, and D. A. Prince
Cortical Injury Affects Short-Term Plasticity of Evoked Excitatory Synaptic Currents
J Neurophysiol, January 1, 2005; 93(1): 146 - 156.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
E. Seiffert, J. P. Dreier, S. Ivens, I. Bechmann, O. Tomkins, U. Heinemann, and A. Friedman
Lasting Blood-Brain Barrier Disruption Induces Epileptic Focus in the Rat Somatosensory Cortex
J. Neurosci., September 8, 2004; 24(36): 7829 - 7836.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
L.-R. Shao and F. E. Dudek
Increased Excitatory Synaptic Activity and Local Connectivity of Hippocampal CA1 Pyramidal Cells in Rats With Kainate-Induced Epilepsy
J Neurophysiol, September 1, 2004; 92(3): 1366 - 1373.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
L. Topolnik, M. Steriade, and I. Timofeev
Partial Cortical Deafferentation Promotes Development of Paroxysmal Activity
Cereb Cortex, August 1, 2003; 13(8): 883 - 893.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. Kobayashi and P. S. Buckmaster
Reduced Inhibition of Dentate Granule Cells in a Model of Temporal Lobe Epilepsy
J. Neurosci., March 15, 2003; 23(6): 2440 - 2452.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. Bacci, J. R. Huguenard, and D. A. Prince
Differential modulation of synaptic transmission by neuropeptide Y in rat neocortical neurons
PNAS, December 24, 2002; 99(26): 17125 - 17130.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online