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The Journal of Neurophysiology Vol. 88 No. 1 July 2002, pp. 333-338
Copyright ©2002 by the American Physiological Society
1Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892; and 2Department of Neurology and Brain Research Institute, Yonsei University College of Medicine, Seoul, 120-752, Korea
Sohn, Young H.,
Katy Wiltz, and
Mark Hallett.
Effect of Volitional Inhibition on Cortical Inhibitory Mechanisms. J. Neurophysiol. 88: 333-338, 2002. To investigate the effect of volitional inhibition on cortical
inhibitory mechanisms, we performed transcranial magnetic stimulation (TMS) studies with a Go/NoGo reaction task in seven healthy subjects. Subjects were asked to extend their right index finger only after Go,
but to remain relaxed after NoGo. Single- and paired-pulse TMS were
triggered at the average reaction time for the Go response in each
subject after Go or NoGo cues. Motor evoked potentials were recorded in
the extensor indicis proprius (EIP) and abductor digiti minimi (ADM)
muscles of right hand. Paired-pulse TMS with subthreshold conditioning
stimuli at interstimulus intervals (ISIs) of 2 ms [short intracortical
inhibition (SICI)] and 15 ms [intracortical facilitation (ICF)] and
that with suprathreshold conditioning stimuli at ISI of 80 ms [long
intracortical inhibition (LICI)] were performed in both Go/NoGo and
control conditions. Inhibition of SICI was enhanced in both EIP and ADM
after NoGo and was reduced only in EIP after Go. Inhibition of LICI was
reduced in both muscles during both conditions, while ICF was not
altered. The present results demonstrate that volitional inhibition
enhances SICI but reduces LICI nonselectively. These results suggest
that these two inhibitory mechanisms act differently during execution
and suppression of voluntary movements.
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