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The Journal of Neurophysiology Vol. 88 No. 2 August 2002, pp. 1016-1025
Copyright ©2002 by the American Physiological Society
Department of Psychology, University of Colorado, Boulder, Colorado 80309-0345
Jones, Michael S. and
Daniel S. Barth.
Effects of Bicuculline Methiodide on Fast (>200 Hz) Electrical
Oscillations in Rat Somatosensory Cortex. J. Neurophysiol. 88: 1016-1025, 2002. Fast
oscillatory activity (more than ~200 Hz) has been attracting
increasing attention regarding its possible role in both normal brain
function and epileptogenesis. Yet, its underlying cellular mechanism
remains poorly understood. Our prior investigation of the phenomenon in
rat somatosensory cortex indicated that fast oscillations result from
repetitive synaptic activation of cortical pyramidal cells originating
from GABAergic interneurons (Jones et al. 2000). To test
this hypothesis, the effects of topical application of the
-aminobutyric acid-A (GABAA) antagonist
bicuculline methiodide (BMI) on fast oscillations were examined. At
subconvulsive concentrations (~10 µM), BMI application resulted in
a pronounced enhancement of fast activity, in some trials doubling the
number of oscillatory cycles evoked by whisker stimulation. The
amplitude and frequency of fast activity were not affected by BMI in a
statistically significant fashion. At higher concentrations, BMI
application resulted in the emergence of recurring spontaneous
slow-wave discharges resembling interictal spikes (IIS) and the
eventual onset of seizure. High-pass filtering of the IIS revealed that
a burst of fast oscillations accompanied the spontaneous discharge.
This activity was present in both the pre- and the postictal regimes,
in which its morphology and spatial distribution were largely
indistinguishable. These data indicate that fast cortical oscillations
do not reflect GABAergic postsynaptic currents. An alternate account
consistent with results observed to date is that this activity may
instead arise from population spiking in pyramidal cells, possibly
mediated by electrotonic coupling in a manner analogous to that
underlying 200-Hz ripple in the hippocampus. Additionally, fast
oscillations occur within spontaneous epileptiform discharges. However,
at least under the present experimental conditions, they do not appear
to be a reliable predictor of seizure onset nor an indicator of the
seizure focus.
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