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The Journal of Neurophysiology Vol. 88 No. 2 August 2002, pp. 1064-1072
Copyright ©2002 by the American Physiological Society
RAPID COMMUNICATION
Centre de Recherche en Sciences Neurologiques, Université de Montréal, C.P. 6128, Succursale Centre-ville, Montreal, Quebec H3C 3J7, Canada
Cisek, Paul and
John F. Kalaska.
Modest Gaze-Related Discharge Modulation in Monkey Dorsal
Premotor Cortex During a Reaching Task Performed With Free
Fixation. J. Neurophysiol. 88: 1064-1072, 2002. Recent studies have shown that gaze angle modulates reach-related
neural activity in many cortical areas, including the dorsal premotor
cortex (PMd), when gaze direction is experimentally controlled by
lengthy periods of imposed fixation. We looked for gaze-related modulation in PMd during the brief fixations that occur when a monkey
is allowed to look around freely without experimentally imposed gaze
control while performing a center-out delayed arm-reaching task. During
the course of the instructed-delay period, we found significant effects
of gaze angle in 27-51% of PMd cells. However, for 90-95% of cells,
these effects accounted for <20% of the observed discharge variance.
The effect of gaze was significantly weaker than the effect of
reach-related variables. In particular, cell activity during the delay
period was more strongly related to the intended movement expressed in
arm-related coordinates than in gaze-related coordinates. Under the
same experimental conditions, many cells in medial parietal cortex
exhibited much stronger gaze-related modulation and expressed intended
movement in gaze-related coordinates. In summary, gaze
direction-related modulation of cell activity is indeed expressed in
PMd during the brief fixations that occur in natural oculomotor
behavior, but its overall effect on cell activity is modest.
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