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J Neurophysiol 88: 1073-1076, 2002;
0022-3077/02 $5.00
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The Journal of Neurophysiology Vol. 88 No. 2 August 2002, pp. 1073-1076
Copyright ©2002 by the American Physiological Society

RAPID COMMUNICATION

Sleep Deprivation Impairs Long-Term Potentiation in Rat Hippocampal Slices

I. G. Campbell,1 M. J. Guinan,2 and J. M. Horowitz2

 1Departments of Psychiatry, and  2Neurobiology Physiology and Behavior, University of California, Davis, California 95616

Campbell, I. G., M. J. Guinan, and J. M. Horowitz. Sleep Deprivation Impairs Long-Term Potentiation in Rat Hippocampal Slices. J. Neurophysiol. 88: 1073-1076, 2002. To determine if 12-h sleep deprivation disrupts neural plasticity, we compared long-term potentiation (LTP) in five sleep-deprived and five control rats. Thirty minutes after tetanus population spike amplitude increased 101 ± 15% in 16 slices from sleep deprived rats and 139 ± 14% in 14 slices from control rats. This significant (P < 0.05) reduction of LTP, the first demonstration that the sleep deprivation protocol impairs plasticity in adult rats, may be due to several factors. Reduced LTP may indicate that sleep provides a period of recuperation for cellular processes underlying neural plasticity. Alternatively, the stress of sleep deprivation, as indicated by elevated blood corticosterone levels, or other non-sleep-specific factors of deprivation may contribute to the LTP reduction.




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