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J Neurophysiol 88: 621-626, 2002;
0022-3077/02 $5.00
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The Journal of Neurophysiology Vol. 88 No. 2 August 2002, pp. 621-626
Copyright ©2002 by the American Physiological Society

17beta -Estradiol Benzoate Decreases the AHP Amplitude in CA1 Pyramidal Neurons

Ashok Kumar and Thomas C. Foster

Department of Molecular and Biomedical Pharmacology, University of Kentucky, College of Medicine, Lexington, Kentucky 40536

Kumar, Ashok and Thomas C. Foster. 17beta -Estradiol Benzoate Decreases the AHP Amplitude in CA1 Pyramidal Neurons. J. Neurophysiol. 88: 621-626, 2002. Disruption of Ca2+ homeostasis is hypothesized to mediate several electrophysiological markers of brain aging. Recent evidence indicates that estradiol can rapidly alter Ca2+-dependent processes in neurons through nongenomic mechanisms. In the current study, electrophysiological effects of 17beta -estradiol benzoate (EB) on the Ca2+-activated afterhyperpolarization (AHP) were investigated using intracellular sharp electrode recording in hippocampal slices from ovariectomized Fischer 344 female rats. The AHP amplitude was enhanced in aged (22-24 mo) compared with young (5-8 mo) rats and direct application of EB (100 pM) reduced the AHP in aged rats. The age-related difference was due, in part, to the increased AHP amplitude of aged animals, since an EB-mediated decrease in the AHP could be observed in young rats when the extracellular Ca2+ was elevated to increase the AHP amplitude. In aged rats, bath application of EB occluded the ability of the L-channel blocker, nifedipine (10 µM), to attenuate the AHP. The results support a role for EB in modifying hippocampal Ca2+-dependent processes in a manner diametrically opposite that observed during aging, possibly through L-channel inhibition.




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