JN Add DOIs to your references at manuscript stage!
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 88: 1270-1278, 2002;
0022-3077/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (44)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lu, Y.-F.
Right arrow Articles by Hawkins, R. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lu, Y.-F.
Right arrow Articles by Hawkins, R. D.

The Journal of Neurophysiology Vol. 88 No. 3 September 2002, pp. 1270-1278
Copyright ©2002 by the American Physiological Society

Ryanodine Receptors Contribute to cGMP-Induced Late-Phase LTP and CREB Phosphorylation in the Hippocampus

Yun-Fei Lu1 and Robert D. Hawkins1,2

 1Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University; and  2New York State Psychiatric Institute, New York, New York 10032

Lu, Yun-Fei and Robert D. Hawkins. Ryanodine Receptors Contribute to cGMP-Induced Late-Phase LTP and CREB Phosphorylation in the Hippocampus. J. Neurophysiol. 88: 1270-1278, 2002. We previously found that the nitric oxide (NO)-cGMP-cGMP-dependent protein kinase (PKG) signaling pathway acts in parallel with the cAMP-cAMP-dependent protein kinase (PKA) pathway to produce protein and RNA synthesis-dependent late-phase long-term potentiation (L-LTP) and cAMP response element-binding protein (CREB) phosphorylation in the CA1 region of mouse hippocampus. We have now investigated the possible involvement of a downstream target of PKG, ryanodine receptors. L-LTP can be induced by either multiple-train tetanization, NO or 8-Br-cGMP paired with one-train tetanization, or the cAMP activator forskolin, and all three types of potentiation are accompanied by an increase in phospho-CREB immunofluorescence in the CA1 cell body area. Both the potentiation and the increase in phospho-CREB immunofluorescence induced by multiple-train tetanization or 8-Br-cGMP paired with one-train tetanization are reduced by prolonged perfusion with ryanodine, which blocks Ca2+ release from ryanodine-sensitive Ca2+ stores. By contrast, neither the potentiation nor the increase in immunofluorescence induced by forskolin are reduced by depletion of ryanodine and inositol-1,4,5-triphosphate (IP3)-sensitive Ca2+ stores. These results suggest that NO, cGMP, and PKG cause release of Ca2+ from ryanodine-sensitive stores, which in turn causes phosphorylation of CREB in parallel with PKA during the induction of L-LTP.




This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
A. T. Huddleston, W. Tang, H. Takeshima, S. L. Hamilton, and E. Klann
Superoxide-Induced Potentiation in the Hippocampus Requires Activation of Ryanodine Receptor Type 3 and ERK
J Neurophysiol, March 1, 2008; 99(3): 1565 - 1571.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T. Kenet, R. C. Froemke, C. E. Schreiner, I. N. Pessah, and M. M. Merzenich
Perinatal exposure to a noncoplanar polychlorinated biphenyl alters tonotopy, receptive fields, and plasticity in rat primary auditory cortex
PNAS, May 1, 2007; 104(18): 7646 - 7651.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
S. Wang, Julian. F. R. Paton, and S. Kasparov
Autonomic Neuroscience: Differential sensitivity of excitatory and inhibitory synaptic transmission to modulation by nitric oxide in rat nucleus tractus solitarii
Exp Physiol, March 1, 2007; 92(2): 371 - 382.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
S. Wang, A. G. Teschemacher, J. F. R. Paton, and S. Kasparov
Mechanism of nitric oxide action on inhibitory GABAergic signaling within the nucleus tractus solitarii
FASEB J, July 1, 2006; 20(9): 1537 - 1539.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. Isokawa and B. E. Alger
Ryanodine Receptor Regulates Endogenous Cannabinoid Mobilization in the Hippocampus
J Neurophysiol, May 1, 2006; 95(5): 3001 - 3011.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Y.-C. Yu, L.-H. Cao, and X.-L. Yang
Modulation by Brain Natriuretic Peptide of GABA Receptors on Rat Retinal ON-Type Bipolar Cells
J. Neurosci., January 11, 2006; 26(2): 696 - 707.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
F. Hofmann, R. Feil, T. Kleppisch, and J. Schlossmann
Function of cGMP-Dependent Protein Kinases as Revealed by Gene Deletion
Physiol Rev, January 1, 2006; 86(1): 1 - 23.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
J.-S. Huang, L.-Y. Chuang, J.-Y. Guh, C.-J. Chen, Y.-L. Yang, T.-A. Chiang, M.-Y. Hung, and T.-N. Liao
Effect of Nitric Oxide-cGMP-Dependent Protein Kinase Activation on Advanced Glycation End-Product-Induced Proliferation in Renal Fibroblasts
J. Am. Soc. Nephrol., August 1, 2005; 16(8): 2318 - 2329.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
A. Verkhratsky
Physiology and Pathophysiology of the Calcium Store in the Endoplasmic Reticulum of Neurons
Physiol Rev, January 1, 2005; 85(1): 201 - 279.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. Aracena, G. Sanchez, P. Donoso, S. L. Hamilton, and C. Hidalgo
S-Glutathionylation Decreases Mg2+ Inhibition and S-Nitrosylation Enhances Ca2+ Activation of RyR1 Channels
J. Biol. Chem., October 31, 2003; 278(44): 42927 - 42935.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. Kleppisch, W. Wolfsgruber, S. Feil, R. Allmann, C. T. Wotjak, S. Goebbels, K.-A. Nave, F. Hofmann, and R. Feil
Hippocampal cGMP-Dependent Protein Kinase I Supports an Age- and Protein Synthesis-Dependent Component of Long-Term Potentiation But Is Not Essential for Spatial Reference and Contextual Memory
J. Neurosci., July 9, 2003; 23(14): 6005 - 6012.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online