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J Neurophysiol 88: 1614-1624, 2002;
0022-3077/02 $5.00
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The Journal of Neurophysiology Vol. 88 No. 4 October 2002, pp. 1614-1624
Copyright ©2002 by the American Physiological Society

P2X Receptors in Trigeminal Subnucleus Caudalis Modulate Central Sensitization in Trigeminal Subnucleus Oralis

Bo Hu,1,* Chen Yu Chiang,1,* James W. Hu,1 Jonathan O. Dostrovsky,2 and Barry J. Sessle1,2

 1Faculty of Dentistry, University of Toronto, Ontario M5G 1G6; and  2Department of Physiology, Faculty of Medicine, University of Toronto, Ontario M5S 1A8, Canada

Hu, Bo, Chen Yu Chiang, James W. Hu, Jonathan O. Dostrovsky, and Barry J. Sessle. P2X Receptors in Trigeminal Subnucleus Caudalis Modulate Central Sensitization in Trigeminal Subnucleus Oralis. J. Neurophysiol. 88: 1614-1624, 2002. This study investigated the role of trigeminal subnucleus caudalis (Vc) P2X receptors in the mediation of central sensitization induced in nociceptive neurons in subnucleus oralis (Vo) by mustard oil (MO) application to the tooth pulp in anesthetized rats. MO application produced a long-lasting central sensitization reflected in neuroplastic changes (i.e., increases in neuronal mechanoreceptive field size and responses to innocuous and noxious mechanical stimuli) in Vo nociceptive neurons. Twenty minutes after MO application, the intrathecal (i.t.) administration to the rostral Vc of the selective P2X1, P2X3, and P2X2/3 receptor antagonist, 2'-(or 3'-)O-trinitrophenyl-ATP (TNP-ATP), significantly and reversibly attenuated the MO-induced central sensitization for more than 15 min; saline administration had no effect. Administration to the rostral Vc of the selective P2X1, P2X3, and P2X2/3 receptor agonist, alpha ,beta -methylene ATP (alpha ,beta -meATP, i.t.) produced abrupt and significant neuroplastic changes in Vo nociceptive neurons, followed by neuronal desensitization as evidenced by the ineffectiveness of a second i.t. application of alpha ,beta -meATP and subsequent MO application to the pulp. Administration to the rostral Vc of the selective P2X1 receptor agonist beta ,gamma -methylene ATP (beta ,gamma -meATP, i.t.) produced no significant neuroplastic changes per se and did not affect the subsequent MO-induced neuroplastic changes in Vo nociceptive neurons. These results suggest that P2X3 and possibly also the P2X2/3 receptor subtypes in Vc may play a role in the initiation and maintenance of central sensitization in Vo nociceptive neurons induced by MO application to the pulp.

* B. Hu and C. Y. Chiang contributed equally to this study.




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