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J Neurophysiol 88: 1915-1923, 2002;
0022-3077/02 $5.00
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The Journal of Neurophysiology Vol. 88 No. 4 October 2002, pp. 1915-1923
Copyright ©2002 by the American Physiological Society

Changes in the Activity of a CPG Neuron After the Reinforcement of an Operantly Conditioned Behavior in Lymnaea

Gaynor E. Spencer,2 Mustapha H. Kazmi,1 Naweed I. Syed,1 and Ken Lukowiak1

 1Neuroscience and Respiratory Research Groups, Departments of Cell Biology and Anatomy, Physiology and Biophysics, Health Sciences Centre, Calgary, Alberta T2N 4N1; and  2Department of Biological Sciences, Brock University, St. Catharines, Ontario L2S 3A1, Canada

Spencer, Gaynor E., Mustapha H. Kazmi, Naweed I. Syed, and Ken Lukowiak. Changes in the Activity of a CPG Neuron After the Reinforcement of an Operantly Conditioned Behavior in Lymnaea. J. Neurophysiol. 88: 1915-1923, 2002. We have previously shown that the aerial respiratory behavior of the mollusk Lymnaea stagnalis can be operantly conditioned, and the central pattern generating (CPG) neurons underlying this behavior have been identified. As neural correlates of operant conditioning remain poorly defined in both vertebrates and invertebrates, we have used the Lymnaea respiratory CPG to investigate neuronal changes associated with the change in behavior after conditioning. After operant conditioning of the intact animals, semi-intact preparations were dissected, so that changes in the respiratory behavior (pneumostome openings) and underlying activity of the identified CPG neuron, right pedal dorsal 1 (RPeD1), could be monitored simultaneously. RPeD1 was studied because it initiates the rhythmic activity of the CPG and receives chemo-sensory input from the pneumostome area. Pneumostome openings and RPeD1 activity were monitored both before and after a reinforcing training stimulus applied to the open pneumostome of operantly conditioned and yoked control preparations. After presentation of the reinforcing stimulus, there was a significant reduction in both breathing behavior and RPeD1 activity in operant preparations but not in yoked and naïve controls. Furthermore these changes were only significant in the subgroup of operantly conditioned animals described as good learners and not in poor learners. These data strongly suggest that changes in RPeD1 activity may underlie the behavioral changes associated with the reinforcement of operant conditioning of the respiratory behavior.




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