| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Neurophysiology Vol. 88 No. 4 October 2002, pp. 1924-1932
Copyright ©2002 by the American Physiological Society
Department of Neuroscience, Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912
Beierlein, Michael and
Barry W. Connors.
Short-Term Dynamics of Thalamocortical and Intracortical Synapses
Onto Layer 6 Neurons in Neocortex. J. Neurophysiol. 88: 1924-1932, 2002. Layer 6 is the main
source of neocortical connections back to specific thalamic nuclei.
Corticothalamic (CT) systems play an important role in shaping sensory
input, but little is known about the functional circuitry that
generates CT activity. We recorded from the two main types of neurons
in layer 6, regular-spiking (RS; pyramidal neurons) and fast-spiking
(FS; inhibitory interneurons) cells and compared the physiological
properties of different excitatory inputs. Thalamic stimulation evoked
two monosynaptic inputs with distinct properties: suspected
thalamocortical (TC) synaptic events had short latencies, short-term
synaptic depression, and paired-pulse responses that suggested
subnormal axonal conduction. A second group of synaptic responses
likely originated from intracortical collaterals of CT cells that were
antidromically activated from the thalamus. These intracortical
responses had longer latencies, short-term synaptic facilitation, and
were transmitted by axons with supernormal conduction. Suspected TC
inputs to FS cells had significantly larger amplitudes than those onto
RS cells. Dual recordings from neighboring neurons in layer 6 revealed
both facilitating and depressing synaptic connections; the depressing
synapses were probably formed by layer 6 cells that do not project to
the thalamus, and thus were not sampled by thalamic stimulation. We
conclude that layer 6 neurons integrate a variety of inputs with
distinct temporal dynamics that are determined by the presynaptic cell type.
This article has been cited by other articles:
|
|
 |
|
  C. Hull, J. S. Isaacson, and M. Scanziani Postsynaptic Mechanisms Govern the Differential Excitation of Cortical Neurons by Thalamic Inputs J. Neurosci., July 15, 2009; 29(28): 9127 - 9136. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Tan, H. Hu, Z. J. Huang, and A. Agmon Robust but delayed thalamocortical activation of dendritic-targeting inhibitory interneurons PNAS, February 12, 2008; 105(6): 2187 - 2192. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. E. Landisman and B. W. Connors VPM and PoM Nuclei of the Rat Somatosensory Thalamus: Intrinsic Neuronal Properties and Corticothalamic Feedback Cereb Cortex, December 1, 2007; 17(12): 2853 - 2865. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Hasenstaub, R. N. S. Sachdev, and D. A. McCormick State Changes Rapidly Modulate Cortical Neuronal Responsiveness J. Neurosci., September 5, 2007; 27(36): 9607 - 9622. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Xu, V. C. Kotak, and D. H. Sanes Conductive Hearing Loss Disrupts Synaptic and Spike Adaptation in Developing Auditory Cortex J. Neurosci., August 29, 2007; 27(35): 9417 - 9426. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Bremaud, D. C. West, and A. M. Thomson Binomial parameters differ across neocortical layers and with different classes of connections in adult rat and cat neocortex PNAS, August 28, 2007; 104(35): 14134 - 14139. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Karayannis, I. Huerta-Ocampo, and M. Capogna GABAergic and Pyramidal Neurons of Deep Cortical Layers Directly Receive and Differently Integrate Callosal Input Cereb Cortex, May 1, 2007; 17(5): 1213 - 1226. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Reig, R. Gallego, L. G. Nowak, and M. V. Sanchez-Vives Impact of Cortical Network Activity on Short-term Synaptic Depression Cereb Cortex, May 1, 2006; 16(5): 688 - 695. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. S. Soteropoulos and S. N. Baker Cortico-Cerebellar Coherence During a Precision Grip Task in the Monkey J Neurophysiol, February 1, 2006; 95(2): 1194 - 1206. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. C. West, A. Mercer, S. Kirchhecker, O. T. Morris, and A. M. Thomson Layer 6 Cortico-thalamic Pyramidal Cells Preferentially Innervate Interneurons and Generate Facilitating EPSPs Cereb Cortex, February 1, 2006; 16(2): 200 - 211. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q.-Q. Sun, J. R. Huguenard, and D. A. Prince Barrel Cortex Microcircuits: Thalamocortical Feedforward Inhibition in Spiny Stellate Cells Is Mediated by a Small Number of Fast-Spiking Interneurons J. Neurosci., January 25, 2006; 26(4): 1219 - 1230. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Mercer, D. C. West, O. T. Morris, S. Kirchhecker, J. E. Kerkhoff, and A. M. Thomson Excitatory Connections Made by Presynaptic Cortico-Cortical Pyramidal Cells in Layer 6 of the Neocortex Cereb Cortex, October 1, 2005; 15(10): 1485 - 1496. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. J. Rose and R. Metherate Auditory Thalamocortical Transmission Is Reliable and Temporally Precise J Neurophysiol, September 1, 2005; 94(3): 2019 - 2030. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. E. Boudreau and D. Ferster Short-Term Depression in Thalamocortical Synapses of Cat Primary Visual Cortex J. Neurosci., August 3, 2005; 25(31): 7179 - 7190. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. T. Porter and D. Nieves Presynaptic GABAB Receptors Modulate Thalamic Excitation of Inhibitory and Excitatory Neurons in the Mouse Barrel Cortex J Neurophysiol, November 1, 2004; 92(5): 2762 - 2770. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Wirth and H.-R. Luscher Spatiotemporal Evolution of Excitation and Inhibition in the Rat Barrel Cortex Investigated With Multielectrode Arrays J Neurophysiol, April 1, 2004; 91(4): 1635 - 1647. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R. Best and D. A. Wilson Coordinate Synaptic Mechanisms Contributing to Olfactory Cortical Adaptation J. Neurosci., January 21, 2004; 24(3): 652 - 660. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Beierlein, J. R. Gibson, and B. W. Connors Two Dynamically Distinct Inhibitory Networks in Layer 4 of the Neocortex J Neurophysiol, November 1, 2003; 90(5): 2987 - 3000. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Li, W. Guido, and M. E. Bickford Two Distinct Types of Corticothalamic EPSPs and Their Contribution to Short-Term Synaptic Plasticity J Neurophysiol, November 1, 2003; 90(5): 3429 - 3440. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
