| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Neurophysiology Vol. 88 No. 4 October 2002, pp. 2019-2034
Copyright ©2002 by the American Physiological Society
The Smith-Kettlewell Eye Research Institute, San Francisco, California 94115
McPeek, Robert M. and
Edward L. Keller.
Saccade Target Selection in the Superior Colliculus During a
Visual Search Task. J. Neurophysiol. 88: 2019-2034, 2002. Because real-world scenes typically contain many
different potential objects of interest, selecting one goal from many
is clearly a fundamental problem faced by the saccadic system. We recorded from visual, movement, and visuo-movement (VM) neurons in the
superior colliculus (SC) of monkeys performing a reaction-time visual-search task requiring them to make saccades to an odd-colored target presented with distractors. First, we compared the responses of
SC neurons in search with their responses when a single target was
presented without distractors (single-stimulus task). Consistent with
earlier reports, initial visual activity was smaller in search than in
the single-stimulus task, while movement-related activity in the two
tasks was comparable. Further experiments showed that much of the
reduction in the initial visual response during search was due to
lateral inhibition, although a top-down task-related component was also
evident. Although the initial visual activity did not discriminate the
target from the distractors, some neurons showed a biphasic pattern of
visual activity. In VM burst neurons, the second phase of this activity
was significantly larger when the target, rather than a distractor, was
in the response field. We traced the time course of target/distractor
discrimination using receiver operating characteristic (ROC)
analysis and found that VM burst neurons, VM prelude neurons, and pure
movement neurons discriminated the target from distractors before
saccade onset but that phasic and tonic pure visual neurons did not. We
also examined the relationship between target/distractor discrimination time and saccade latency. Discrimination in VM burst neurons having a
biphasic pattern of visual activity and in many VM prelude neurons occurred after a consistent delay that did not depend on saccade latency, suggesting that these neurons are involved in target selection
as well as movement initiation. In contrast, VM burst neurons lacking a
biphasic pattern of visual activity, pure movement neurons, and a
subset of VM prelude neurons discriminated the target at a time that
was well correlated with saccade latency, suggesting that this latter
group of neurons is involved in triggering movement execution but not
in target selection. Thus a mix of signals likely related to target
selection and movement initiation co-exists in different groups of SC
neurons. This suggests that certain types of SC neurons participate in
the target selection process and that the SC as a whole represents a
gateway for target selection signals to be converted into a saccadic command.
This article has been cited by other articles:
|
|
 |
|
  M. Isoda and O. Hikosaka A Neural Correlate of Motivational Conflict in the Superior Colliculus of the Macaque J Neurophysiol, September 1, 2008; 100(3): 1332 - 1342. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Liu and M. A. Basso Substantia Nigra Stimulation Influences Monkey Superior Colliculus Neuronal Activity Bilaterally J Neurophysiol, August 1, 2008; 100(2): 1098 - 1112. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Rezvani and B. D. Corneil Recruitment of a Head-Turning Synergy by Low-Frequency Activity in the Primate Superior Colliculus J Neurophysiol, July 1, 2008; 100(1): 397 - 411. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. McPeek Reversal of a Distractor Effect on Saccade Target Selection After Superior Colliculus Inactivation J Neurophysiol, May 1, 2008; 99(5): 2694 - 2702. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Li and M. A. Basso Preparing to Move Increases the Sensitivity of Superior Colliculus Neurons J. Neurosci., April 23, 2008; 28(17): 4561 - 4577. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Kim and M. A. Basso Saccade Target Selection in the Superior Colliculus: A Signal Detection Theory Approach J. Neurosci., March 19, 2008; 28(12): 2991 - 3007. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-H. Song, N. Takahashi, and R. M. McPeek Target Selection for Visually Guided Reaching in Macaque J Neurophysiol, January 1, 2008; 99(1): 14 - 24. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Ikeda and O. Hikosaka Positive and Negative Modulation of Motor Response in Primate Superior Colliculus by Reward Expectation J Neurophysiol, December 1, 2007; 98(6): 3163 - 3170. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Schall, M. Pare, and G. F. Woodman Comment on "Top-Down Versus Bottom-Up Control of Attention in the Prefrontal and Posterior Parietal Cortices" Science, October 5, 2007; 318(5847): 44b - 44b. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. F. Woodman, S. J. Luck, and J. D. Schall The Role of Working Memory Representations in the Control of Attention Cereb Cortex, September 1, 2007; 17(suppl_1): i118 - i124. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Marin, C. Salas, E. Sentis, X. Rojas, J. C. Letelier, and J. Mpodozis A Cholinergic Gating Mechanism Controlled by Competitive Interactions in the Optic Tectum of the Pigeon J. Neurosci., July 25, 2007; 27(30): 8112 - 8121. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Alvarado, J. W. Vaughan, T. R. Stanford, and B. E. Stein Multisensory Versus Unisensory Integration: Contrasting Modes in the Superior Colliculus J Neurophysiol, May 1, 2007; 97(5): 3193 - 3205. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Ratcliff, Y. T. Hasegawa, R. P. Hasegawa, P. L. Smith, and M. A. Segraves Dual Diffusion Model for Single-Cell Recording Data From the Superior Colliculus in a Brightness-Discrimination Task J Neurophysiol, February 1, 2007; 97(2): 1756 - 1774. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Murthy, S. Ray, S. M. Shorter, E. G. Priddy, J. D. Schall, and K. G. Thompson Frontal Eye Field Contributions to Rapid Corrective Saccades J Neurophysiol, February 1, 2007; 97(2): 1457 - 1469. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. W. D. Thomas and M. Pare Temporal Processing of Saccade Targets in Parietal Cortex Area LIP During Visual Search J Neurophysiol, January 1, 2007; 97(1): 942 - 947. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. McPeek Incomplete Suppression of Distractor-Related Activity in the Frontal Eye Field Results in Curved Saccades J Neurophysiol, November 1, 2006; 96(5): 2699 - 2711. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-M. Lee and E. L. Keller Symbolic Cue-Driven Activity in Superior Colliculus Neurons in a Peripheral Visual Choice Task J Neurophysiol, June 1, 2006; 95(6): 3585 - 3595. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Ipata, A. L. Gee, M. E. Goldberg, and J. W. Bisley Activity in the lateral intraparietal area predicts the goal and latency of saccades in a free-viewing visual search task. J. Neurosci., April 5, 2006; 26(14): 3656 - 3661. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Li, B. Kim, and M. A. Basso Transient Pauses in Delay-Period Activity of Superior Colliculus Neurons J Neurophysiol, April 1, 2006; 95(4): 2252 - 2264. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Li and M. A. Basso Competitive Stimulus Interactions within Single Response Fields of Superior Colliculus Neurons J. Neurosci., December 7, 2005; 25(49): 11357 - 11373. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. Fecteau and D. P. Munoz Correlates of Capture of Attention and Inhibition of Return across Stages of Visual Processing J. Cogn. Neurosci., November 1, 2005; 17(11): 1714 - 1727. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Pouget, E. E. Emeric, V. Stuphorn, K. Reis, and J. D. Schall Chronometry of Visual Responses in Frontal Eye Field, Supplementary Eye Field, and Anterior Cingulate Cortex J Neurophysiol, September 1, 2005; 94(3): 2086 - 2092. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Blohm, M. Missal, and P. Lefevre Direct Evidence for a Position Input to the Smooth Pursuit System J Neurophysiol, July 1, 2005; 94(1): 712 - 721. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Krauzlis The Control of Voluntary Eye Movements: New Perspectives Neuroscientist, April 1, 2005; 11(2): 124 - 137. [Abstract] [PDF]
|
|
|
|
|
|
K. G. Thompson, N. P. Bichot, and T. R. Sato Frontal Eye Field Activity Before Visual Search Errors Reveals the Integration of Bottom-Up and Top-Down Salience J Neurophysiol, January 1, 2005; 93(1): 337 - 351. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-H. Juan, S. M. Shorter-Jacobi, and J. D. Schall Dissociation of spatial attention and saccade preparation PNAS, October 26, 2004; 101(43): 15541 - 15544. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Fecteau, A. H. Bell, and D. P. Munoz Neural Correlates of the Automatic and Goal-Driven Biases in Orienting Spatial Attention J Neurophysiol, September 1, 2004; 92(3): 1728 - 1737. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Krauzlis Activity of Rostral Superior Colliculus Neurons During Passive and Active Viewing of Motion J Neurophysiol, August 1, 2004; 92(2): 949 - 958. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Ogawa and H. Komatsu Target Selection in Area V4 during a Multidimensional Visual Search Task J. Neurosci., July 14, 2004; 24(28): 6371 - 6382. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. O'Shea, N. G. Muggleton, A. Cowey, and V. Walsh Timing of Target Discrimination in Human Frontal Eye Fields J. Cogn. Neurosci., July 1, 2004; 16(6): 1060 - 1067. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. T. Wyder, D. P. Massoglia, and T. R. Stanford Contextual Modulation of Central Thalamic Delay-Period Activity: Representation of Visual and Saccadic Goals J Neurophysiol, June 1, 2004; 91(6): 2628 - 2648. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Arai, R. M. McPeek, and E. L. Keller Properties of Saccadic Responses in Monkey When Multiple Competing Visual Stimuli Are Present J Neurophysiol, February 1, 2004; 91(2): 890 - 900. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. McPeek, J. H. Han, and E. L. Keller Competition Between Saccade Goals in the Superior Colliculus Produces Saccade Curvature J Neurophysiol, May 1, 2003; 89(5): 2577 - 2590. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
