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J Neurophysiol (November 1, 2002). 10.1152/jn.00083.2002
Submitted on 6 February 2002
Accepted on 11 July 2002
Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China
He, Jufang
OFF Responses in the Auditory Thalamus of the Guinea
Pig. J. Neurophysiol. 88: 2377-2386, 2002. ON and OFF auditory responses were
examined in the medial geniculate body (MGB) of the guinea pig. Single-
and multiunit recordings were carried out on 12 anesthetized animals,
and noise-burst or pure-tone stimuli were applied to the ear
contralateral to the recording hemisphere. One hundred and thirty-five
OFF or ON-OFF neurons and 160 ON
neurons were studied, and the tuning curves of 21 ON-OFF or
OFF neurons were examined from various nuclei of the MGB.
The mean minimum threshold of the OFF responses (40.8 ± 20.0 dB SPL, mean ± SD; range: 0-80 dB SPL) was
significantly higher than that of the ON responses
(28.5 ± 17.6 dB SPL, range: 0-60 dB SPL; n = 17, P < 0.001). Of 10 ON-OFF neurons that
showed identifiable tuning frequencies for both ON and
OFF responses, 7 showed a higher OFF than
ON best frequency (BF), 2 showed the same BF for both
ON and OFF, and only 1 showed a slightly lower OFF than ON BF. Most OFF responses
sampled from the borders of the ventral (MGv) and the rostromedial
(MGrm) nuclei of the MGB showed single-peaked tuning curves, similar to
those of the ON responses in the MGv. The neurons located
in the shell (MGs) and dorsal (MGd) nuclei of the MGB showed
complicated
either multi-peaked or broadtuning curves. All
OFF responses showed long-duration-selectivity for acoustic
stimuli: the mean half-maximum duration was 116.5 ± 114.8 ms
(n = 19, range: 27-411 ms). The latencies of 135 OFF responses were studied in various divisions of the MGB.
The ventral border region of MGv showed the shortest latency, followed
by the dorsal border region of the MGv, the MGrm, and the caudomedial nucleus (MGcm) of the MGB. The posterior nucleus of the thalamus (Po),
the MGd, and the MGs showed much longer mean latencies of >30 ms
(P < 0.05 compared with the border regions of the MGv, ANOVA), with Po showing the greatest mean latency of 60.3 ms and the
greatest deviation of 25.5 ms). The latency of the OFF
response (29.0 ± 14.0 ms, n = 135) was
significantly greater than that of the ON response
(15.6 ± 9.6 ms, n = 160, P < 0.001). The present results provide valuable information about the
threshold, frequency tuning characteristics, minimal response latency,
and duration selectivity of OFF neurons in the auditory thalamus.
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