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J Neurophysiol (November 1, 2002). 10.1152/jn.00598.2002
Submitted on 18 March 2002
Accepted on 24 July 2002
Department of Biomedical Engineering, Center for BioDynamics, Boston University, Boston, Massachusetts 02215
Haas, Julie S. and
John A. White.
Frequency Selectivity of Layer II Stellate Cells in the Medial
Entorhinal Cortex. J. Neurophysiol. 88: 2422-2429, 2002. Electrophysiologically, stellate cells (SCs)
from layer II of the medial entorhinal cortex (MEC) are distinguished
by intrinsic 4- to 12-Hz subthreshold oscillations. These oscillations
are thought to impose a pattern of slow periodic firing that may
contribute to the parahippocampal theta rhythm in vivo. Using stimuli
with systematically differing frequency content, we examined supra- and
subthreshold responses in SCs with the goal of understanding how their
distinctive characteristics shape these responses. In reaction to
repeated presentations of identical, pseudo-random stimuli, the
reliability (repeatability) of the spiking response in SCs depends
critically on the frequency content of the stimulus. Reliability is
optimal for stimuli with a greater proportion of power in the 4- to
12-Hz range. The simplest mechanistic explanation of these results is
that rhythmogenic subthreshold membrane mechanisms resonate with inputs
containing significant power in the 4- to 12-Hz band, leading to larger
subthreshold excursions and thus enhanced reliability. However, close
examination of responses rules out this explanation: SCs do show clear
subthreshold resonance (i.e., selective amplification of inputs with
particular frequency content) in response to sinusoidal stimuli, while
simultaneously showing a lack of subthreshold resonance in response to
the pseudo-random stimuli used in reliability experiments. Our results
support a model with distinctive input-output relationships under
subthreshold and suprathreshold conditions. For suprathreshold stimuli,
SC spiking seems to best reflect the amount of input power in the theta
(4-12 Hz) frequency band. For subthreshold stimuli, we hypothesize that the magnitude of subthreshold theta-range oscillations in SCs
reflects the total power, across all frequencies, of the input.
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