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J Neurophysiol 88: 2899-2908, 2002; doi:10.1152/jn.00037.2002
0022-3077/02 $5.00
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J Neurophysiol (December 1, 2002). 10.1152/jn.00037.2002
Submitted on 17 January 2002
Accepted on 22 August 2002

Synaptically Evoked GABA Transporter Currents in Neocortical Glia

Gregory A. Kinney1,2,4 and William J. Spain1,3,4

 1Veterans Affairs Puget Sound Health Care System, Seattle, 98108; and Departments of  2Rehabilitation Medicine,  3Neurology, and  4Physiology and Biophysics, University of Washington School of Medicine, Seattle, Washington 98195

Kinney, Gregory A. and William J. Spain. Synaptically Evoked GABA Transporter Currents in Neocortical Glia. J. Neurophysiol. 88: 2899-2908, 2002. The presence, magnitude, and time course of GABA transporter currents were investigated in electrophysiologically characterized neocortical astrocytes in an in vitro slice preparation. On stimulation with a bipolar-tungsten stimulating electrode placed nearby, the majority of cells tested displayed long-lasting GABA transporter currents using both single and repetitive stimulation protocols. Using subtype-specific GABA transporter antagonists, long-lasting GABA transporter currents were identified in neocortical astrocytes that originated from at least two subtypes of GABA transporters: GAT-1 and GAT-2/3. These transporter currents displayed slow rise times and long decay times, contrasting the time course observed for glutamate transporter currents, and are indicative of a long extracellular time course of GABA as well as a role for glial GABA transporters during synaptic transmission.




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