JN Watch the video to see how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 88: 3097-3107, 2002; doi:10.1152/jn.00026.2002
0022-3077/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (18)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Banks, M. I.
Right arrow Articles by Pearce, R. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Banks, M. I.
Right arrow Articles by Pearce, R. A.

J Neurophysiol (December 1, 2002). 10.1152/jn.00026.2002
Submitted on 14 January 2002
Accepted on 5 August 2002

Development of GABAA Receptor-Mediated Inhibitory Postsynaptic Currents in Hippocampus

Matthew I. Banks, Jason B. Hardie, and Robert A. Pearce

Department of Anesthesiology and Neuroscience Training Program, University of Wisconsin, Madison, Wisconsin 53706

Banks, Matthew I., Jason B. Hardie, and Robert A. Pearce. Development of GABAA Receptor-Mediated Inhibitory Postsynaptic Currents in Hippocampus. J. Neurophysiol. 88: 3097-3107, 2002. Hippocampal CA1 pyramidal cells receive two kinetic classes of GABAA receptor-mediated inhibition: slow dendritic inhibitory postsynaptic currents (GABAA,slow IPSCs) and fast perisomatic (GABAA,fast) IPSCs. These two classes of IPSCs are likely generated by two distinct groups of interneurons, and we have previously shown that the kinetics of the IPSCs have important functional consequences for generating synchronous firing patterns. Here, we studied developmental changes in the properties of GABAA,fast and GABAA,slow spontaneous, miniature, and evoked IPSCs (sIPSCs, mIPSCs, and eIPSCs, respectively) using whole cell voltage-clamp recordings in brain slices from animals aged P10-P35. We found that the rate of GABAA,slow sIPSCs increased by over 70-fold between P11 and P35 (from 0.0017 to 0.12 s-1). Over this same age range, we observed a >3.5-fold increase in the maximal amplitude of GABAA,slow eIPSCs evoked by stratum lacunosum-moleculare (SL-M) stimuli. However, the rate and amplitude of GABAA,slow mIPSCs remained unchanged between P10 and P30, suggesting that the properties of GABAA,slow synapses remained stable over this age range, and that the increase in sIPSC rate and in eIPSC amplitude was due to increased excitability or excitation of GABAA,slow interneurons. This hypothesis was tested using bath application of norepinephrine (NE), which we found at low concentrations (1 µM) selectively increased the rate of GABAA,slow sIPSCs while leaving GABAA,fast sIPSCs unchanged. This effect was observed in animals as young as P13 and was blocked by coapplication of tetrodotoxin, suggesting that NE was acting to increase the spontaneous firing rate of GABAA,slow interneurons and consistent with our hypothesis that developmental changes in GABAA,slow IPSCs are due to changes in presynaptic excitability. In contrast to the changes we observed in GABAA,slow IPSCs, the properties of GABAA,fast sIPSCs remained largely constant between P11 and P35, whereas the rate, amplitude, and kinetics of GABAA,fast mIPSCs showed significant changes between P10 and P30, suggesting counterbalancing changes in action potential-dependent GABAA,fast sIPSCs. These observations suggest differential developmental regulation of the firing properties of GABAA,fast and GABAA,slow interneurons in CA1 between P10 and P35.




This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
E. D. Zarnowska, R. Keist, U. Rudolph, and R. A. Pearce
GABAA Receptor {alpha}5 Subunits Contribute to GABAA,slow Synaptic Inhibition in Mouse Hippocampus
J Neurophysiol, March 1, 2009; 101(3): 1179 - 1191.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
F. N. Karameh and S. G. Massaquoi
Intracortical Augmenting Responses in Networks of Reduced Compartmental Models of Tufted Layer 5 Cells
J Neurophysiol, January 1, 2009; 101(1): 207 - 233.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
V. C. Kotak, A. E. Takesian, and D. H. Sanes
Hearing Loss Prevents the Maturation of GABAergic Transmission in the Auditory Cortex
Cereb Cortex, September 1, 2008; 18(9): 2098 - 2108.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
V. Zsiros and G. Maccaferri
Noradrenergic Modulation of Electrical Coupling in GABAergic Networks of the Hippocampus
J. Neurosci., February 20, 2008; 28(8): 1804 - 1815.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
G. A. Prenosil, E. M. Schneider Gasser, U. Rudolph, R. Keist, J.-M. Fritschy, and K. E. Vogt
Specific Subtypes of GABAA Receptors Mediate Phasic and Tonic Forms of Inhibition in Hippocampal Pyramidal Neurons
J Neurophysiol, August 1, 2006; 96(2): 846 - 857.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. Azimi-Zonooz, C. W. Shuttleworth, and J. A. Connor
GABAergic Protection of Hippocampal Pyramidal Neurons Against Glutamate Insult: Deficit in Young Animals Compared to Adults
J Neurophysiol, July 1, 2006; 96(1): 299 - 308.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. Glykys and I. Mody
Hippocampal Network Hyperactivity After Selective Reduction of Tonic Inhibition in GABAA Receptor {alpha}5 Subunit-Deficient Mice
J Neurophysiol, May 1, 2006; 95(5): 2796 - 2807.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. S. Esposito, V. C. Piatti, D. A. Laplagne, N. A. Morgenstern, C. C. Ferrari, F. J. Pitossi, and A. F. Schinder
Neuronal Differentiation in the Adult Hippocampus Recapitulates Embryonic Development
J. Neurosci., November 2, 2005; 25(44): 10074 - 10086.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
R. Jabs, T. Pivneva, K. Huttmann, A. Wyczynski, C. Nolte, H. Kettenmann, and C. Steinhauser
Synaptic transmission onto hippocampal glial cells with hGFAP promoter activity
J. Cell Sci., August 15, 2005; 118(16): 3791 - 3803.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
C.-Y. Chen and A. C. Bonham
Glutamate suppresses GABA release via presynaptic metabotropic glutamate receptors at baroreceptor neurones in rats
J. Physiol., January 15, 2005; 562(2): 535 - 551.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
N. J. Allen, D. J. Rossi, and D. Attwell
Sequential Release of GABA by Exocytosis and Reversed Uptake Leads to Neuronal Swelling in Simulated Ischemia of Hippocampal Slices
J. Neurosci., April 14, 2004; 24(15): 3837 - 3849.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
R. M. Meredith, A. M. Floyer-Lea, and O. Paulsen
Maturation of Long-Term Potentiation Induction Rules in Rodent Hippocampus: Role of GABAergic Inhibition
J. Neurosci., December 3, 2003; 23(35): 11142 - 11146.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Bacci, U. Rudolph, J. R. Huguenard, and D. A. Prince
Major Differences in Inhibitory Synaptic Transmission onto Two Neocortical Interneuron Subclasses
J. Neurosci., October 22, 2003; 23(29): 9664 - 9674.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online