JN Information on EB 2010
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 88: 3259-3278, 2002; doi:10.1152/jn.00770.2001
0022-3077/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (18)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Brichta, A. M.
Right arrow Articles by Goldberg, J. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brichta, A. M.
Right arrow Articles by Goldberg, J. M.

J Neurophysiol (December 1, 2002). 10.1152/jn.00770.2001
Submitted on 17 September 2001
Accepted on 28 June 2002

Regional Analysis of Whole Cell Currents From Hair Cells of the Turtle Posterior Crista

Alan M. Brichta,1 Anne Aubert,3 Ruth Anne Eatock,3 and Jay M. Goldberg2

Departments of  1Otolaryngology-Head and Neck Surgery and  2Neurobiology, Pharmacology and Physiology, University of Chicago, Chicago, Illinois 60637; and  3The Bobby R. Alford Department of Otorhinolaryngology and Communicative Sciences, Baylor College of Medicine, Houston, Texas 77030

Brichta, Alan M., Anne Aubert, Ruth Anne Eatock, and Jay M. Goldberg. Regional Analysis of Whole Cell Currents From Hair Cells of the Turtle Posterior Crista. J. Neurophysiol. 88: 3259-3278, 2002. The turtle posterior crista is made up of two hemicristae, each consisting of a central zone containing type I and type II hair cells and a surrounding peripheral zone containing only type II hair cells and extending from the planum semilunatum to the nonsensory torus. Afferents from various regions of a hemicrista differ in their discharge properties. To see if afferent diversity is related to the basolateral currents of the hair cells innervated, we selectively harvested type I and II hair cells from the central zone and type II hair cells from two parts of the peripheral zone, one near the planum and the other near the torus. Voltage-dependent currents were studied with the whole cell, ruptured-patch method and characterized in voltage-clamp mode. We found regional differences in both outwardly and inwardly rectifying voltage-sensitive currents. As in birds and mammals, type I hair cells have a distinctive outwardly rectifying current (IK,L), which begins activating at more hyperpolarized voltages than do the outward currents of type II hair cells. Activation of IK,L is slow and sigmoidal. Maximal outward conductances are large. Outward currents in type II cells vary in their activation kinetics. Cells with fast kinetics are associated with small conductances and with partial inactivation during 200-ms depolarizing voltage steps. Almost all type II cells in the peripheral zone and many in the central zone have fast kinetics. Some type II cells in the central zone have large outward currents with slow kinetics and little inactivation. Although these currents resemble IK,L, they can be distinguished from the latter both electrophysiologically and pharmacologically. There are two varieties of inwardly rectifying currents in type II hair cells: activation of IK1 is rapid and monoexponential, whereas that of Ih is slow and sigmoidal. Many type II cells either have both inward currents or only have IK1; very few cells only have Ih. Inward currents are less conspicuous in type I cells. Type II cells near the torus have smaller outwardly rectifying currents and larger inwardly rectifying currents than those near the planum, but the differences are too small to account for variations in discharge properties of bouton afferents innervating the two regions of the peripheral zone. The large outward conductances seen in central cells, by lowering impedances, may contribute to the low rotational gains of some central-zone afferents.




This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
J. C. Holt, S. Chatlani, A. Lysakowski, and J. M. Goldberg
Quantal and Nonquantal Transmission in Calyx-Bearing Fibers of the Turtle Posterior Crista
J Neurophysiol, September 1, 2007; 98(3): 1083 - 1101.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. R. A. Wooltorton, S. Gaboyard, K. M. Hurley, S. D. Price, J. L. Garcia, M. Zhong, A. Lysakowski, and R. A. Eatock
Developmental Changes in Two Voltage-Dependent Sodium Currents in Utricular Hair Cells
J Neurophysiol, February 1, 2007; 97(2): 1684 - 1704.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. C. Holt, A. Lysakowski, and J. M. Goldberg
Mechanisms of Efferent-Mediated Responses in the Turtle Posterior Crista
J. Neurosci., December 20, 2006; 26(51): 13180 - 13193.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. H. Rowe and E. H. Peterson
Autocorrelation Analysis of Hair Bundle Structure in the Utricle
J Neurophysiol, November 1, 2006; 96(5): 2653 - 2669.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
K. M. Hurley, S. Gaboyard, M. Zhong, S. D. Price, J. R. A. Wooltorton, A. Lysakowski, and R. A. Eatock
M-Like K+ Currents in Type I Hair Cells and Calyx Afferent Endings of the Developing Rat Utricle
J. Neurosci., October 4, 2006; 26(40): 10253 - 10269.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
K. J. Rennie and M. A. Streeter
Voltage-Dependent Currents in Isolated Vestibular Afferent Calyx Terminals
J Neurophysiol, January 1, 2006; 95(1): 26 - 32.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. C. Holt, J.-T. Xue, A. M. Brichta, and J. M. Goldberg
Transmission Between Type II Hair Cells and Bouton Afferents in the Turtle Posterior Crista
J Neurophysiol, January 1, 2006; 95(1): 428 - 452.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
S. M. Highstein, R. D. Rabbitt, G. R. Holstein, and R. D. Boyle
Determinants of Spatial and Temporal Coding by Semicircular Canal Afferents
J Neurophysiol, May 1, 2005; 93(5): 2359 - 2370.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. D. Rabbitt, R. Boyle, G. R. Holstein, and S. M. Highstein
Hair-Cell Versus Afferent Adaptation in the Semicircular Canals
J Neurophysiol, January 1, 2005; 93(1): 424 - 436.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
G. S. G. Geleoc, J. R. Risner, and J. R. Holt
Developmental Acquisition of Voltage-Dependent Conductances and Sensory Signaling in Hair Cells of the Embryonic Mouse Inner Ear
J. Neurosci., December 8, 2004; 24(49): 11148 - 11159.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
M. J. Correia, T. G. Wood, D. Prusak, T. Weng, K. J. Rennie, and H.-Q. Wang
Molecular characterization of an inward rectifier channel (IKir) found in avian vestibular hair cells: cloning and expression of pKir2.1
Physiol Genomics, October 4, 2004; 19(2): 155 - 169.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
H. Bao, W. H. Wong, J. M. Goldberg, and R. A. Eatock
Voltage-Gated Calcium Channel Currents in Type I and Type II Hair Cells Isolated From the Rat Crista
J Neurophysiol, July 1, 2003; 90(1): 155 - 164.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. M. Goldberg and A. M. Brichta
Functional Analysis of Whole Cell Currents From Hair Cells of the Turtle Posterior Crista
J Neurophysiol, December 1, 2002; 88(6): 3279 - 3292.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online