JN Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 89: 324-337, 2003; doi:10.1152/jn.00729.2002
0022-3077/03 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (16)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Doiron, B.
Right arrow Articles by Turner, R. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Doiron, B.
Right arrow Articles by Turner, R. W.

J Neurophysiol (January 1, 2003). 10.1152/jn.00729.2002
Submitted on Submitted 26 August 2002; accepted in final form 20 September 2002

Persistent Na+ Current Modifies Burst Discharge By Regulating Conditional Backpropagation of Dendritic Spikes

Brent Doiron,1 Liza Noonan,2 Neal Lemon,2 and Ray W. Turner2

 1Department of Physics, University of Ottawa, Ottawa, Ontario K1N 6N5;  2Neuroscience Research Group, Department of Cell Biology and Anatomy, University of Calgary, Calgary, Alberta, T2N 4N1 Canada

Doiron, Brent, Liza Noonan, Neal Lemon, and Ray W. Turner. Persistent Na+ Current Modifies Burst Discharge By Regulating Conditional Backpropagation of Dendritic Spikes. J. Neurophysiol. 89: 324-337, 2003. The estimation and detection of stimuli by sensory neurons is affected by factors that govern a transition from tonic to burst mode and the frequency chracteristics of burst output. Pyramidal cells in the electrosensory lobe of weakly electric fish generate spike bursts for the purpose of stimulus detection. Spike bursts are generated during repetitive discharge when a frequency-dependent broadening of dendritic spikes increases current flow from dendrite to soma to potentiate a somatic depolarizing afterpotential (DAP). The DAP eventually triggers a somatic spike doublet with an interspike interval that falls inside the dendritic refractory period, blocking spike backpropagiation and the DAP. Repetition of this process gives rise to a rhythmic dendritic spike failure, termed conditional backpropagation, that converts cell output from tonic to burst discharge. Through in vitro recordings and compartmental modeling we show that burst frequency is regulated by the rate of DAP potentiation during a burst, which determines the time required to discharge the spike doublet that blocks backpropagation. DAP potentiation is maginfied through a postitve feedback process when an increase in dendritic spike duration activates persistent sodium current (INaP). INaP further promotes a slow depolarization that induces a shift from tonic to burst discharge over time. The results are consistent with a dynamical systems analysis that shows that the threshold separating tonic and burst discharge can be represented as a saddle-node bifurcation. The interaction between dendritic K+ current and INaP provides a physiological explanation for a variable time scale of bursting dynamics characteristic of such a bifurcation.




This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
N. Toporikova and M. J. Chacron
SK Channels Gate Information Processing In Vivo by Regulating an Intrinsic Bursting Mechanism Seen In Vitro
J Neurophysiol, October 1, 2009; 102(4): 2273 - 2287.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
W. H. Mehaffey, L. Maler, and R. W. Turner
Intrinsic Frequency Tuning in ELL Pyramidal Cells Varies Across Electrosensory Maps
J Neurophysiol, May 1, 2008; 99(5): 2641 - 2655.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
L. D. Ellis, R. Krahe, C. W. Bourque, R. J. Dunn, and M. J. Chacron
Muscarinic Receptors Control Frequency Tuning Through the Downregulation of an A-Type Potassium Current
J Neurophysiol, September 1, 2007; 98(3): 1526 - 1537.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
L. D. Ellis, W. H. Mehaffey, E. Harvey-Girard, R. W. Turner, L. Maler, and R. J. Dunn
SK Channels Provide a Novel Mechanism for the Control of Frequency Tuning in Electrosensory Neurons
J. Neurosci., August 29, 2007; 27(35): 9491 - 9502.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
B. Doiron, A.-M. M. Oswald, and L. Maler
Interval Coding. II. Dendrite-Dependent Mechanisms
J Neurophysiol, April 1, 2007; 97(4): 2744 - 2757.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
G. La Camera, A. Rauch, D. Thurbon, H.-R. Luscher, W. Senn, and S. Fusi
Multiple Time Scales of Temporal Response in Pyramidal and Fast Spiking Cortical Neurons
J Neurophysiol, December 1, 2006; 96(6): 3448 - 3464.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
T. C. Pappas, M. Motamedi, and B. N. Christensen
Unique temperature-activated neurons from pit viper thermosensors
Am J Physiol Cell Physiol, November 1, 2004; 287(5): C1219 - C1228.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A.-M. M. Oswald, M. J. Chacron, B. Doiron, J. Bastian, and L. Maler
Parallel Processing of Sensory Input by Bursts and Isolated Spikes
J. Neurosci., May 5, 2004; 24(18): 4351 - 4362.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. Curti and A. E. Pereda
Voltage-Dependent Enhancement of Electrical Coupling by a Subthreshold Sodium Current
J. Neurosci., April 21, 2004; 24(16): 3999 - 4010.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
L. Noonan, B. Doiron, C. Laing, A. Longtin, and R. W. Turner
A Dynamic Dendritic Refractory Period Regulates Burst Discharge in the Electrosensory Lobe of Weakly Electric Fish
J. Neurosci., February 15, 2003; 23(4): 1524 - 1534.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online