JN Add DOIs to your references at manuscript stage!
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 89: 1016-1023, 2003. First published October 30, 2002; doi:10.1152/jn.00562.2002
0022-3077/03 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
89/2/1016    most recent
00562.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (57)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by DeSouza, J. F. X.
Right arrow Articles by Everling, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by DeSouza, J. F. X.
Right arrow Articles by Everling, S.

J Neurophysiol (February 1, 2003). 10.1152/jn.00562.2002
Submitted on Submitted 15 July 2002; accepted in final form 26 September 2002

Preparatory Set Associated With Pro-Saccades and Anti-Saccades in Humans Investigated With Event-Related fMRI

Joseph F. X. DeSouza,1 Ravi S. Menon,2 and Stefan Everling1,3

 1Department of Physiology, University of Western Ontario, London, Ontario N6A 5C1;  2The Laboratory for Magnetic Resonance Research, The John P. Robarts Research Institute, London, Ontario N6A 5K8: and  3Department of Psychology, University of Western Ontario, London, Ontario N6A 5C2, Canada

DeSouza, Joseph F. X., Ravi S. Menon, and Stefan Everling. Preparatory Set Associated With Pro-Saccades and Anti-Saccades in Humans Investigated With Event-Related fMRI. J. Neurophysiol. 89: 1016-1023, 2003. Previous studies have shown that the BOLD functional MRI (fMRI) signal is increased in several cortical areas when subjects perform anti-saccades compared with pro-saccades. It remains unknown, however, whether this increase is due to an increased cortical motor signal for anti-saccades or due to differences in preparatory set between pro- and anti-saccade trials. To address this question, we measured event-related fMRI in a paradigm that allowed us to separate instruction-related brain activity from saccade-related brain activity. In this paradigm, the instruction to either generate a pro-saccade or an anti-saccade was conveyed by a switch in the color of the central fixation stimulus and preceded the presentation of a peripheral stimulus by either 6, 10, or 14 s. Cortical areas were functionally mapped using the general linear model comparing standard pro- and anti-saccade blocks with fixation blocks. When the trials were aligned on the onset of the instruction stimulus, bilateral frontal eye fields and right hemisphere dorsolateral prefrontal cortex showed an increased signal during the instruction period on anti-saccade trials as compared with pro-saccade trials. When the trials were aligned on the movement stimulus and the instruction period activity was subtracted, there were no differences between pro- and anti-saccades. This finding suggests that the increased cortical activation found in previous blocked designs originates predominately from differences in preparatory set and not from differences in the motor signal between pro- and anti-saccades.




This article has been cited by other articles:


Home page
 BrainHome page
K. N. Thakkar, F. E. Polli, R. M. Joseph, D. S. Tuch, N. Hadjikhani, J. J.S. Barton, and D. S. Manoach
Response monitoring, repetitive behaviour and anterior cingulate abnormalities in autism spectrum disorders (ASD)
Brain, September 1, 2008; 131(9): 2464 - 2478.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
U. Ettinger, D. H. ffytche, V. Kumari, N. Kathmann, B. Reuter, F. Zelaya, and S. C. R. Williams
Decomposing the Neural Correlates of Antisaccade Eye Movements Using Event-Related fMRI
Cereb Cortex, May 1, 2008; 18(5): 1148 - 1159.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
C. E. Curtis and J. D. Connolly
Saccade Preparation Signals in the Human Frontal and Parietal Cortices
J Neurophysiol, January 1, 2008; 99(1): 133 - 145.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. R. G. Brown, T. Vilis, and S. Everling
Frontoparietal Activation With Preparation for Antisaccades
J Neurophysiol, September 1, 2007; 98(3): 1751 - 1762.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
T. Hodgson, M. Chamberlain, B. Parris, M. James, N. Gutowski, M. Husain, and C. Kennard
The role of the ventrolateral frontal cortex in inhibitory oculomotor control
Brain, June 1, 2007; 130(6): 1525 - 1537.
[Abstract] [Full Text] [PDF]

Home page
 J. Cogn. Neurosci.Home page
A. T. Herdman and J. D. Ryan
Spatio-temporal Brain Dynamics Underlying Saccade Execution, Suppression, and Error-related Feedback.
J. Cogn. Neurosci., March 1, 2007; 19(3): 420 - 432.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
D. S. Manoach, K. N. Thakkar, M. S. Cain, F. E. Polli, J. A. Edelman, B. Fischl, and J. J. S. Barton
Neural Activity Is Modulated by Trial History: A Functional Magnetic Resonance Imaging Study of the Effects of a Previous Antisaccade
J. Neurosci., February 14, 2007; 27(7): 1791 - 1798.
[Abstract] [Full Text] [PDF]

Home page
 J. Cogn. Neurosci.Home page
J. Chikazoe, S. Konishi, T. Asari, K. Jimura, and Y. Miyashita
Activation of Right Inferior Frontal Gyrus during Response Inhibition across Response Modalities.
J. Cogn. Neurosci., January 1, 2007; 19(1): 69 - 80.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
S. M. Beurze, F. P. de Lange, I. Toni, and W. P. Medendorp
Integration of Target and Effector Information in the Human Brain During Reach Planning
J Neurophysiol, January 1, 2007; 97(1): 188 - 199.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. J. Heinen, J. Rowland, B.-T. Lee, and A. R. Wade
An Oculomotor Decision Process Revealed by Functional Magnetic Resonance Imaging
J. Neurosci., December 27, 2006; 26(52): 13515 - 13522.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
L. H. Snyder, A. R. Dickinson, and J. L. Calton
Preparatory Delay Activity in the Monkey Parietal Reach Region Predicts Reach Reaction Times
J. Neurosci., October 4, 2006; 26(40): 10091 - 10099.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
B. M. Lawrence and L. H. Snyder
Comparison of Effector-Specific Signals in Frontal and Parietal Cortices
J Neurophysiol, September 1, 2006; 96(3): 1393 - 1400.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. L. Boxer, S. Garbutt, K. P. Rankin, J. Hellmuth, J. Neuhaus, B. L. Miller, and S. G. Lisberger
Medial versus lateral frontal lobe contributions to voluntary saccade control as revealed by the study of patients with frontal lobe degeneration.
J. Neurosci., June 7, 2006; 26(23): 6354 - 6363.
[Abstract] [Full Text] [PDF]

Home page
 J. Cogn. Neurosci.Home page
M. Raemaekers, M. Vink, M. P. van den Heuvel, R. S. Kahn, and N. F. Ramsey
Effects of aging on BOLD fMRI during prosaccades and antisaccades.
J. Cogn. Neurosci., April 1, 2006; 18(4): 594 - 603.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
B. Olk, E. Chang, A. Kingstone, and T. Ro
Modulation of Antisaccades by Transcranial Magnetic Stimulation of the Human Frontal Eye Field
Cereb Cortex, January 1, 2006; 16(1): 76 - 82.
[Abstract] [Full Text] [PDF]

Home page
 J. Cogn. Neurosci.Home page
S. Everling and J. F. X. DeSouza
Rule-dependent Activity for Prosaccades and Antisaccades in the Primate Prefrontal Cortex
J. Cogn. Neurosci., September 1, 2005; 17(9): 1483 - 1496.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
K. A. Ford, H. C. Goltz, M. R. G. Brown, and S. Everling
Neural Processes Associated With Antisaccade Task Performance Investigated With Event-Related fMRI
J Neurophysiol, July 1, 2005; 94(1): 429 - 440.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. D. Connolly, M. A. Goodale, H. C. Goltz, and D. P. Munoz
fMRI Activation in the Human Frontal Eye Field Is Correlated With Saccadic Reaction Time
J Neurophysiol, July 1, 2005; 94(1): 605 - 611.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
W. P. Medendorp, H. C. Goltz, and T. Vilis
Remapping the Remembered Target Location for Anti-Saccades in Human Posterior Parietal Cortex
J Neurophysiol, July 1, 2005; 94(1): 734 - 740.
[Abstract] [Full Text] [PDF]

Home page
 Ann. N. Y. Acad. Sci.Home page
C. PIERROT-DESEILLIGNY, R M MURI, T NYFFELER, and D MILEA
The Role of the Human Dorsolateral Prefrontal Cortex in Ocular Motor Behavior
Ann. N.Y. Acad. Sci., April 1, 2005; 1039(1): 239 - 251.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. J. Marotta, G. P. Keith, and J. D. Crawford
Task-Specific Sensorimotor Adaptation to Reversing Prisms
J Neurophysiol, February 1, 2005; 93(2): 1104 - 1110.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. E. Curtis, V. Y. Rao, and M. D'Esposito
Maintenance of Spatial and Motor Codes during Oculomotor Delayed Response Tasks
J. Neurosci., April 21, 2004; 24(16): 3944 - 3952.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
R. J. Leigh and C. Kennard
Using saccades as a research tool in the clinical neurosciences
Brain, March 1, 2004; 127(3): 460 - 477.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M.R.G. Brown, J.F.X. DeSouza, H. C. Goltz, K. Ford, R. S. Menon, M. A. Goodale, and S. Everling
Comparison of Memory- and Visually Guided Saccades Using Event-Related fMRI
J Neurophysiol, February 1, 2004; 91(2): 873 - 889.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online