JN Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 89: 1057-1066, 2003. First published October 30, 2002; doi:10.1152/jn.00938.2002
0022-3077/03 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
89/2/1057    most recent
00938.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (28)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Manns, I. D.
Right arrow Articles by Jones, B. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Manns, I. D.
Right arrow Articles by Jones, B. E.

J Neurophysiol (February 1, 2003). 10.1152/jn.00938.2002
Submitted on Submitted 7 June 2002; accepted in final form 22 October 2002

Rhythmically Discharging Basal Forebrain Units Comprise Cholinergic, GABAergic, and Putative Glutamatergic Cells

Ian D. Manns, Angel Alonso, and Barbara E. Jones

Department of Neurology and Neurosurgery, McGill University, Montreal Neurological Institute, Montreal, Quebec H3A 2B4, Canada

Manns, Ian D., Angel Alonso, and Barbara E. Jones. Rhythmically Discharging Basal Forebrain Units Comprise Cholinergic, GABAergic, and Putative Glutamatergic Cells. J. Neurophysiol. 89: 1057-1066, 2003. The basal forebrain plays important roles in arousal, learning, and memory by stimulating cortical activation characterized by rhythmic slow theta and high-frequency beta-gamma activities. Although cholinergic neurons play a significant part in these roles, other, including GABAergic, neurons appear to contribute. Using juxtacellular labeling with neurobiotin of neurons recorded within the magnocellular preoptic-substantia innominata area in urethan-anesthetized rats, we show that in addition to cells that are cholinergic or GABAergic, other cells that are neither fire rhythmically in correlation with stimulation-induced rhythmic slow activity on the cortex. Neurons with the characteristics of the noncholinergic/nonGABAergic cells contain phosphate-activated glutaminase (PAG), the synthetic enzyme for transmitter glutamate and may thus be glutamatergic. Within their oscillatory spike trains, putative glutamatergic neurons fire at a lower frequency (~20 Hz) than the GABAergic neurons (~40 Hz) and the cholinergic neurons (average: 75 Hz), whose spike trains include high-frequency bursts. The three groups all discharge rhythmically at a slow frequency in correlation with rhythmic slow activity recorded on the prefrontal, entorhinal, piriform and olfactory bulb cortices. The predominant slow frequency corresponds to the respiratory-olfactory rhythm, which is commonly slower than, yet can be as fast as, the hippocampal theta rhythm during certain coordinated behaviors, such as sniffing-whisking. While stimulating higher frequency beta-gamma activities, putative glutamatergic together with GABAergic and cholinergic cells may thus collectively modulate rhythmic slow activity and thereby promote coherent processing and plasticity across distributed cortical networks during coordinated behaviors and states.




This article has been cited by other articles:


Home page
 J. Neurosci.Home page
O. K. Hassani, M. G. Lee, P. Henny, and B. E. Jones
Discharge Profiles of Identified GABAergic in Comparison to Cholinergic and Putative Glutamatergic Basal Forebrain Neurons across the Sleep-Wake Cycle
J. Neurosci., September 23, 2009; 29(38): 11828 - 11840.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. Boucetta and B. E. Jones
Activity Profiles of Cholinergic and Intermingled GABAergic and Putative Glutamatergic Neurons in the Pontomesencephalic Tegmentum of Urethane-Anesthetized Rats
J. Neurosci., April 8, 2009; 29(14): 4664 - 4674.
[Abstract] [Full Text] [PDF]

Home page
 Learn. Mem.Home page
N. Boix-Trelis, A. Vale-Martinez, G. Guillazo-Blanch, D. Costa-Miserachs, and M. Marti-Nicolovius
Effects of nucleus basalis magnocellularis stimulation on a socially transmitted food preference and c-Fos expression
Learn. Mem., November 1, 2006; 13(6): 783 - 793.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. Wolansky, E. A. Clement, S. R. Peters, M. A. Palczak, and C. T. Dickson
Hippocampal slow oscillation: a novel EEG state and its coordination with ongoing neocortical activity.
J. Neurosci., June 7, 2006; 26(23): 6213 - 6229.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
T. E. Fitch, R. N. Sahr, B. J. Eastwood, F. C. Zhou, and C. R. Yang
Dopamine D1/5 Receptor Modulation of Firing Rate and Bidirectional Theta Burst Firing in Medial Septal/Vertical Limb of Diagonal Band Neurons In Vivo
J Neurophysiol, May 1, 2006; 95(5): 2808 - 2820.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. G.J. Allen, F. C. Abogadie, and D. A. Brown
Simultaneous Release of Glutamate and Acetylcholine from Single Magnocellular "Cholinergic" Basal Forebrain Neurons
J. Neurosci., February 1, 2006; 26(5): 1588 - 1595.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. G. Lee, O. K. Hassani, A. Alonso, and B. E. Jones
Cholinergic Basal Forebrain Neurons Burst with Theta during Waking and Paradoxical Sleep
J. Neurosci., April 27, 2005; 25(17): 4365 - 4369.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. M. Kay
Theta oscillations and sensorimotor performance
PNAS, March 8, 2005; 102(10): 3863 - 3868.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. G. Lee, I. D. Manns, A. Alonso, and B. E. Jones
Sleep-Wake Related Discharge Properties of Basal Forebrain Neurons Recorded With Micropipettes in Head-Fixed Rats
J Neurophysiol, August 1, 2004; 92(2): 1182 - 1198.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
F Sotty, M Danik, F Manseau, F Laplante, R Quirion, and S Williams
Distinct electrophysiological properties of glutamatergic, cholinergic and GABAergic rat septohippocampal neurons: novel implications for hippocampal rhythmicity
J. Physiol., September 15, 2003; 551(3): 927 - 943.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online