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J Neurophysiol 89: 1150-1160, 2003; doi:10.1152/jn.00475.2002
0022-3077/03 $5.00
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J Neurophysiol (February 1, 2003). 10.1152/jn.00475.2002
Submitted on Submitted 28 June 2002; accepted in final form 24 September 2002

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Effects of High-Frequency Stimulation in the Internal Globus Pallidus on the Activity of Thalamic Neurons in the Awake Monkey

Marjorie E. Anderson,1,2,3,4 Nadia Postupna,2,4 and Mark Ruffo2,3,4

Departments of  1Rehabilitation Medicine, and  2Physiology and Biophysics,  3Graduate Program in Neurobiology and Behavior, and  4Regional Primate Research Center, University of Washington, Seattle, Washington, 98195

Anderson, Marjorie E., Nadia Postupna, and Mark Ruffo. Effects of High-Frequency Stimulation in the Internal Globus Pallidus on the Activity of Thalamic Neurons in the Awake Monkey. J. Neurophysiol. 89: 1150-1160, 2003. The reduction in symptoms of Parkinson's disease produced by high-frequency stimulation (HFS) in the internal globus pallidus (GPi) has been proposed to be due to stimulus-induced inactivation of pallidal neurons and resulting disinhibition of thalamic neurons. We tested this in awake Macaca fascicularis by stimulating between pairs of electrodes inserted into GPi under electrophysiological control and recording the responses evoked in thalamic neurons. HFS produced a reduction, not an increase, in discharge frequency during the stimulus train in 77% of the responsive thalamic neurons. Only 16% of the responsive cells showed an increase in discharge during stimulation and, for some of these, stimulation at a similar intensity produced contralateral muscle contraction, a probable sign of current spread to the internal capsule. The few thalamic neurons studied during bursting had a reduction in burst frequency and duration during HFS. We conclude that high-frequency stimulation within GPi does not necessarily facilitate thalamic discharge, and it may act, instead, to interrupt abnormal patterns of thalamic discharge associated with parkinsonian symptoms.




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