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J Neurophysiol (February 1, 2003). 10.1152/jn.00558.2002
Submitted on Submitted 15 July 2002; accepted in final form 16 October 2002
Department of Cognitive Neurology, University of Tübingen, 72076 Tübingen, Germany
Pedroarena, Christine M. and
Cornelius Schwarz.
Efficacy and Short-Term Plasticity at GABAergic Synapses Between
Purkinje and Cerebellar Nuclei Neurons. J. Neurophysiol. 89: 704-715, 2003. Although the entire
output of the cerebellar cortex is conveyed to the deep cerebellar
nuclei neurons (DCNs) via the GABAergic synapses established by
Purkinje cells (PCs), very little is known about the strength and
dynamic properties of PC-DCN connections. Here we show that activation
of PC-DCN unitary connections induced large conductance changes (11.7 nS) in DCNs recorded in whole cell patch configuration in acute slices,
suggesting that activity of single PCs might significantly affect the
output of its target neurons. Based on the large unitary quantal
content (18) inferred from calculations of PC-DCN quantal size (0.65 nS) and the near absence of failures in synaptic transmission during
control conditions, we conclude that PC-DCN connections are highly
multi-sited. The analysis of dynamic properties of PC-DCN synapses
demonstrated remarkable paired pulse depression (PPD), maximal at short
intervals (paired pulse ratio of 0.15 at 7-ms interval). We provide
evidence that PPD is presynaptic in origin and release-independent. In addition, multiple pulse stimulation revealed that PC-DCN synapses exhibited larger sensitivity to dynamic than to steady signals. We
postulate that the, otherwise paradoxical, combination of marked short-term depression with strong multi-sited connections is optimal to
transfer dynamic information at unitary level by performing spatial
average of release probability across the numerous release sites. This
feature could enable these synapses to encode presynaptic time-varying
signals of single PCs as moment-to-moment changes in synaptic strength,
a capacity well suited to the postulated role of cerebellum in control
of temporal aspects of motor or cognitive behaviors.
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