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J Neurophysiol 89: 1196-1204, 2003; doi:10.1152/jn.00553.2002
0022-3077/03 $5.00
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J Neurophysiol (March 1, 2003). 10.1152/jn.00553.2002
Submitted on Submitted 13 July 2002; accepted in final form 14 October 2002

Effect of Extracellular Calcium on Excitability of Guinea Pig Airway Vagal Afferent Nerves

Bradley J. Undem,1 Eun Joo Oh,2 Eric Lancaster,2 and Daniel Weinreich2

 1Johns Hopkins School of Medicine, Department of Medicine 21224; and  2University of Maryland, Department of Pharmacology, Baltimore, Maryland 21201

Undem, Bradley J., Eun Joo Oh, Eric Lancaster, and Daniel Weinreich. Effect of Extracellular Calcium on Excitability of Guinea Pig Airway Vagal Afferent Nerves. J. Neurophysiol. 89: 1196-1204, 2003. The effect of reducing extracellular calcium concentration ([Ca2+]o) on vagal afferent excitability was analyzed in a guinea pig isolated vagally innervated trachea-bronchus preparation. Afferent fibers were characterized as either having low-threshold, rapidly adapting mechanosensors (Adelta fibers) or nociceptive-like phenotypes (Adelta and C fibers). The nociceptors were derived from neurons within the jugular ganglia, whereas the low-threshold mechanosensors were derived from neurons within the nodose ganglia. Reducing [Ca2+]o did not affect the excitability of the low-threshold mechanosensors in the airway. By contrast, reducing [Ca2+]o selectively increased the excitability of airway nociceptors as manifested by a substantive increase in action potential discharge in response to mechanical stimulation, and in a subset of fibers, by overtly evoking action potential discharge. This increase in the excitability of nociceptors was not mimicked by a combination of omega -conotoxin and nifedipine or tetraethylammonium. Whole cell patch recordings from airway-labeled and unlabeled neurons in the vagal jugular ganglia support the hypothesis that [Ca2+]o inhibits a nonselective cation conductance in vagal nociceptors that may serve to regulate excitability of the nerve terminals within the airways.




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