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J Neurophysiol (March 1, 2003). 10.1152/jn.0892.2002
Submitted on Submitted 4 October 2002; accepted in final form 14 November 2002
1Department of Genetics; 2Department of Molecular Biophysics and Biochemistry, and 3Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520; and 4Organic Synthesis Core Facility, Sloan-Kettering Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center, New York, New York 10021
Moresco, Eva Marie Yang,
Alfred J. Scheetz,
William
G. Bornmann,
Anthony J. Koleske, and
Reiko Maki Fitzsimonds.
Abl Family Nonreceptor Tyrosine Kinases Modulate Short-Term
Synaptic Plasticity. J. Neurophysiol. 89: 1678-1687, 2003. Abl family nonreceptor tyrosine kinases regulate
cell morphogenesis through functional interactions with the actin
cytoskeleton. The vertebrate Abl family kinases, Abl and Arg, are
expressed in the adult mouse brain, where they may regulate actin
cytoskeletal dynamics in mature neurons. Using immunoelectron
microscopy, we have localized Abl and Arg to the pre- and postsynaptic
compartments of synapses in the mouse hippocampal area CA1.
Paired-pulse facilitation (PPF) was significantly reduced at the
Schaffer collateral-CA1 (SC-CA1) excitatory synapses in hippocampal
slices from abl
/ and arg/ mice as
compared with wild-type mice. Furthermore, treatment of wild-type
slices with the specific Abl family kinase inhibitor STI571 also
reduced PPF. Basal synaptic transmission, posttetanic potentiation
(PTP), long-term potentiation (LTP), and long-term depression (LTD)
were similar to wild-type controls in abl/ and
arg/ slices and in STI571-treated wild-type slices. These results indicate that an important function of Abl and Arg is to
modulate synaptic efficacy via a presynaptic mechanism during repetitive activation.
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