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J Neurophysiol (April 1, 2003). 10.1152/jn.00972.2002
Submitted on Submitted 28 October 2002; accepted in final form 5 December 2002
Department of Zoology, University of Washington, Seattle, Washington 98195
Picken Bahrey, Heidi L. and
William
J. Moody.
Early Development of Voltage-Gated Ion Currents and Firing
Properties in Neurons of the Mouse Cerebral Cortex. J. Neurophysiol. 89: 1761-1773, 2003. Voltage- and current-clamp recordings were made from acute slices
of mouse cerebral cortex from embryonic day 14 to postnatal day 17. We
targeted cells in the migratory population of the embryonic intermediate zone (IZ) and in deep layers of embryonic and postnatal cortical plate (CP). IZ neurons maintain fairly consistent properties through the embryonic period, all expressing high-input resistance, inward Na+ currents and outward
K+ currents, and none showing any
hyperpolarization-activated currents. In CP neurons, several changes in
physiological properties occur in the late embryonic and early
postnatal period: inward Na+ current density is
strongly upregulated while outward K+ current
density remains almost unchanged, input resistance drops dramatically,
and a hyperpolarization-activated current resembling Ih appears. As a result of these
changes, the action potential becomes larger, shorter in duration, and
its threshold shifts to more negative potentials. In addition, CP cells
become capable of firing repetitively and an increasing fraction show
spontaneous action potentials. This coordinated development of ion
channel properties may help to time the occurrence of developmentally relevant spontaneous activity in the immature cortex.
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