| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Neurophysiol (April 1, 2003). 10.1152/jn.00972.2002
Submitted on Submitted 28 October 2002; accepted in final form 5 December 2002
Department of Zoology, University of Washington, Seattle, Washington 98195
Picken Bahrey, Heidi L. and
William
J. Moody.
Early Development of Voltage-Gated Ion Currents and Firing
Properties in Neurons of the Mouse Cerebral Cortex. J. Neurophysiol. 89: 1761-1773, 2003. Voltage- and current-clamp recordings were made from acute slices
of mouse cerebral cortex from embryonic day 14 to postnatal day 17. We
targeted cells in the migratory population of the embryonic intermediate zone (IZ) and in deep layers of embryonic and postnatal cortical plate (CP). IZ neurons maintain fairly consistent properties through the embryonic period, all expressing high-input resistance, inward Na+ currents and outward
K+ currents, and none showing any
hyperpolarization-activated currents. In CP neurons, several changes in
physiological properties occur in the late embryonic and early
postnatal period: inward Na+ current density is
strongly upregulated while outward K+ current
density remains almost unchanged, input resistance drops dramatically,
and a hyperpolarization-activated current resembling Ih appears. As a result of these
changes, the action potential becomes larger, shorter in duration, and
its threshold shifts to more negative potentials. In addition, CP cells
become capable of firing repetitively and an increasing fraction show
spontaneous action potentials. This coordinated development of ion
channel properties may help to time the occurrence of developmentally relevant spontaneous activity in the immature cortex.
This article has been cited by other articles:
|
|
 |
|
  A. R. Moore, R. Filipovic, Z. Mo, M. N. Rasband, N. Zecevic, and S. D. Antic Electrical Excitability of Early Neurons in the Human Cerebral Cortex during the Second Trimester of Gestation Cereb Cortex, August 1, 2009; 19(8): 1795 - 1805. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. M. Howard, Zhicheng Mo, R. Filipovic, A. R. Moore, S. D. Antic, and N. Zecevic Radial Glia Cells in the Developing Human Brain Neuroscientist, October 1, 2008; 14(5): 459 - 473. [Abstract] [PDF]
|
|
|
|
 |
|
 S. Rheims, M. Minlebaev, A. Ivanov, A. Represa, R. Khazipov, G. L. Holmes, Y. Ben-Ari, and Y. Zilberter Excitatory GABA in Rodent Developing Neocortex In Vitro J Neurophysiol, August 1, 2008; 100(2): 609 - 619. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. V. Chirila, K. C. Rowland, J. M. Thompson, and G. A. Spirou Development of gerbil medial superior olive: integration of temporally delayed excitation and inhibition at physiological temperature J. Physiol., October 1, 2007; 584(1): 167 - 190. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Reboreda, R. Raouf, A. Alonso, and P. Seguela Development of Cholinergic Modulation and Graded Persistent Activity in Layer V of Medial Entorhinal Cortex J Neurophysiol, June 1, 2007; 97(6): 3937 - 3947. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Johnson, J. P. Weick, R. A. Pearce, and S.-C. Zhang Functional Neural Development from Human Embryonic Stem Cells: Accelerated Synaptic Activity via Astrocyte Coculture J. Neurosci., March 21, 2007; 27(12): 3069 - 3077. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. K. McCabe, S. L. Chisholm, H. L. Picken-Bahrey, and W. J. Moody The self-regulating nature of spontaneous synchronized activity in developing mouse cortical neurones J. Physiol., November 15, 2006; 577(1): 155 - 167. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. K. Goetz, B. Scheffler, H.-X. Chen, S. Wang, O. Suslov, H. Xiang, O. Brustle, S. N. Roper, and D. A. Steindler Temporally restricted substrate interactions direct fate and specification of neural precursors derived from embryonic stem cells PNAS, July 18, 2006; 103(29): 11063 - 11068. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-C. Platel, S. Boisseau, A. Dupuis, J. Brocard, A. Poupard, M. Savasta, M. Villaz, and M. Albrieux Na+ channel-mediated Ca2+ entry leads to glutamate secretion in mouse neocortical preplate PNAS, December 27, 2005; 102(52): 19174 - 19179. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. C. Moe, M. Varghese, A. I. Danilov, U. Westerlund, J. Ramm-Pettersen, L. Brundin, M. Svensson, J. Berg-Johnsen, and I. A. Langmoen Multipotent progenitor cells from the adult human brain: neurophysiological differentiation to mature neurons Brain, September 1, 2005; 128(9): 2189 - 2199. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. J. Moody and M. M. Bosma Ion Channel Development, Spontaneous Activity, and Activity-Dependent Development in Nerve and Muscle Cells Physiol Rev, July 1, 2005; 85(3): 883 - 941. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R Chittajallu, A Aguirre, and V Gallo NG2-positive cells in the mouse white and grey matter display distinct physiological properties J. Physiol., November 15, 2004; 561(1): 109 - 122. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Corlew, M. M Bosma, and W. J Moody Spontaneous, synchronous electrical activity in neonatal mouse cortical neurones J. Physiol., October 15, 2004; 560(2): 377 - 390. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. S. Overstreet, S. T. Hentges, V. F. Bumaschny, F. S. J. de Souza, J. L. Smart, A. M. Santangelo, M. J. Low, G. L. Westbrook, and M. Rubinstein A Transgenic Marker for Newly Born Granule Cells in Dentate Gyrus J. Neurosci., March 31, 2004; 24(13): 3251 - 3259. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z.-w. Zhang Maturation of Layer V Pyramidal Neurons in the Rat Prefrontal Cortex: Intrinsic Properties and Synaptic Function J Neurophysiol, March 1, 2004; 91(3): 1171 - 1182. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Albrieux, J.-C. Platel, A. Dupuis, M. Villaz, and W. J. Moody Early Expression of Sodium Channel Transcripts and Sodium Current by Cajal-Retzius Cells in the Preplate of the Embryonic Mouse Neocortex J. Neurosci., February 18, 2004; 24(7): 1719 - 1725. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
