| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Neurophysiol (April 1, 2003). 10.1152/jn.00630.2002
Submitted on Submitted 2 August 2002; accepted in final form 19 December 2002
1Department of Mathematical Engineering and Information Physics, The University of Tokyo, Tokyo 113-8656; 2Laboratory for Mathematical Neuroscience, RIKEN Brain Science Institute, Saitama 351-0198; 3School of Knowledge Science, Japan Advanced Institute of Science and Technology, Ishikawa 923-1292; 4Department of Physiology, Juntendo University, School of Medicine, Tokyo 113-8421; and 5Core Research for the Evolutional Science and Technology Program, Japan Science and Technology Corporation, Saitama 332-0012, Japan
Itoh, Hideaki,
Hiroyuki Nakahara,
Okihide Hikosaka,
Reiko Kawagoe,
Yoriko Takikawa, and
Kazuyuki Aihara.
Correlation of Primate Caudate Neural Activity and Saccade
Parameters in Reward-Oriented Behavior. J. Neurophysiol. 89: 1774-1783, 2003. Changes in the reward
context are associated with changes in neuronal activity in the basal
ganglia as well as changes in motor outputs. A typical example is found
in the caudate (CD) projection neurons and saccade parameters. It
raised the possibility that the changes in CD neuronal activity
contribute to the changes in saccade parameters. To examine this
possibility, we calculated the correlation coefficients (CORs) of the
firing rates of each neuron with saccade parameters (peak saccade
velocity and latency) on a trial-by-trial basis. We then calculated the
mean CORs separately for two CD populations: reward-enhanced type
neurons (RENs) that showed enhanced activity and reward-depressed type
neurons (RDNs) that showed depressed activity when reward was expected.
The activity of RENs was positively correlated with the saccadic peak
velocity and negatively correlated with the saccade latency. The
activity of RDNs was not significantly correlated with the saccade
parameters. We further analyzed the CORs for RENs, a major type of CD
neurons. First, we examined the time courses of the CORs using a moving time window (duration: 200 ms). The positive correlation with the
saccade velocity and the negative correlation with the saccade latency
were present not only in the peri-saccadic period but also during the
pre- and postcue periods. Second, we asked whether the CORs with the
saccade parameters were direction-selective. A majority of RENs were
more active before contralateral saccades (contralateral-preferring
neurons) and their activity was correlated more strongly with
contralateral saccades than with ipsilateral saccades. A minority of
RENs, ipsilateral-preferring neurons, showed no such preference. These
results are consistent with the hypothesis that CD neuronal activity
exerts facilitatory effects on contralateral saccades and that the
effects start well before saccade execution. Furthermore, a multiple
regression analysis indicated that changes in activity of some, but not
all, CD neurons could be explained by changes in saccade parameters; a
major determinant was reward context (presence or absence of reward).
These results suggest that, while a majority of CD neurons receive
reward-related signals, only some of them can make a significant
contribution to change saccadic outputs based on expected reward.
This article has been cited by other articles:
|
|
 |
|
  B. Lau and P. W. Glimcher Action and Outcome Encoding in the Primate Caudate Nucleus J. Neurosci., December 26, 2007; 27(52): 14502 - 14514. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Ikeda and O. Hikosaka Positive and Negative Modulation of Motor Response in Primate Superior Colliculus by Reward Expectation J Neurophysiol, December 1, 2007; 98(6): 3163 - 3170. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Taha, S. M. Nicola, and H. L. Fields Cue-evoked encoding of movement planning and execution in the rat nucleus accumbens J. Physiol., November 1, 2007; 584(3): 801 - 818. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Pasquereau, A. Nadjar, D. Arkadir, E. Bezard, M. Goillandeau, B. Bioulac, C. E. Gross, and T. Boraud Shaping of Motor Responses by Incentive Values through the Basal Ganglia J. Neurosci., January 31, 2007; 27(5): 1176 - 1183. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Ramat, R. J. Leigh, D. S. Zee, and L. M. Optican What clinical disorders tell us about the neural control of saccadic eye movements Brain, January 1, 2007; 130(1): 10 - 35. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Amiez, J.P. Joseph, and E. Procyk Reward Encoding in the Monkey Anterior Cingulate Cortex Cereb Cortex, July 1, 2006; 16(7): 1040 - 1055. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Nakamura and O. Hikosaka Role of dopamine in the primate caudate nucleus in reward modulation of saccades. J. Neurosci., May 17, 2006; 26(20): 5360 - 5369. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Hikosaka, K. Nakamura, and H. Nakahara Basal Ganglia Orient Eyes to Reward J Neurophysiol, February 1, 2006; 95(2): 567 - 584. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Watanabe and O. Hikosaka Immediate Changes in Anticipatory Activity of Caudate Neurons Associated With Reversal of Position-Reward Contingency J Neurophysiol, September 1, 2005; 94(3): 1879 - 1887. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Takikawa, R. Kawagoe, and O. Hikosaka A Possible Role of Midbrain Dopamine Neurons in Short- and Long-Term Adaptation of Saccades to Position-Reward Mapping J Neurophysiol, October 1, 2004; 92(4): 2520 - 2529. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Nicola, I. A. Yun, K. T. Wakabayashi, and H. L. Fields Cue-Evoked Firing of Nucleus Accumbens Neurons Encodes Motivational Significance During a Discriminative Stimulus Task J Neurophysiol, April 1, 2004; 91(4): 1840 - 1865. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Kawagoe, Y. Takikawa, and O. Hikosaka Reward-Predicting Activity of Dopamine and Caudate Neurons--A Possible Mechanism of Motivational Control of Saccadic Eye Movement J Neurophysiol, February 1, 2004; 91(2): 1013 - 1024. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Watanabe, J. Lauwereyns, and O. Hikosaka Neural Correlates of Rewarded and Unrewarded Eye Movements in the Primate Caudate Nucleus J. Neurosci., November 5, 2003; 23(31): 10052 - 10057. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
