| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Neurophysiol (April 1, 2003). 10.1152/jn.00832.2002
Submitted on Submitted 19 September 2002; accepted in final form 27 November
2002
Sobell Department of Neurophysiology, Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom
Baker, Stuart N.,
Elizabeth M. Pinches, and
Roger N. Lemon.
Synchronization in Monkey Motor Cortex During a Precision Grip
Task. II. Effect of Oscillatory Activity on Corticospinal Output. J. Neurophysiol. 89: 1941-1953, 2003. Recordings from primary motor cortex (M1) during periods of steady
contraction show oscillatory activity; these oscillations are coherent
with the activity of contralateral muscles. We investigated synchronization of corticospinal output neurons with the oscillations, which could provide the pathway for their transmission to the spinal
motoneurons. One hundred seventy-six antidromically identified pyramidal tract neurons (PTNs) were recorded from M1 in three macaque
monkeys trained to perform a precision grip task. Local field
potentials (LFP) were simultaneously recorded. All analysis was
confined to the hold period of the task, where our previous work has
shown that there is the strongest oscillatory activity. Coherence was
calculated between LFP and PTN discharge. Significant coherence was
seen in three bands, with frequencies of 10-14, 17-31, and 34-44 Hz.
Coherence values were low, with the majority of PTN-LFP coherences
having a peak lower than 0.05. The phase of coherence was approximately
/2 radians for each band (with LFP polarity defined as negative
upward), although there was some dispersion of phase across the
population of PTNs. Coherence was also calculated between pairs of PTNs
that had been simultaneously recorded. Where there was significant
coherence, it was also generally smaller than 0.05. The phase of
PTN-PTN coherence clustered around zero radians. A computer model was
constructed to assist the interpretation of the experimental results.
It simulated an integrate-and-fire neuron responding to synaptic
inputs. A fraction of the synaptic inputs was synchronized with a
simulated LFP; the remainder were uncorrelated with it. The model
showed that coherence between the LFP and the output spike train
considerably underestimated the fraction of synchronized inputs.
Additionally, for a given fraction of synchronized inputs, coherence
was smaller for high- compared with low-frequency bins. Cell discharge
rate also influenced the spike-LFP coherence: coherence was higher for
simulations in which the cell discharged at a faster rate. Thus
although levels of PTN-LFP coherence seen experimentally were low, a
considerable proportion of the input to the PTN must be synchronized
with the global oscillatory activity recorded by the LFP. The low
LFP-PTN coherences do however indicate that cortical oscillations are transmitted with only low fidelity in the discharge of a single PTN.
Using further computer simulations, it was demonstrated that a small
population of PTNs could encode the cortical oscillatory signal
effectively, since the action of averaging across the population improves the signal:noise ratio. The oscillations will therefore be
effectively transmitted to spinal motoneurons, and this has important
consequences for the possible role of oscillations in motor control of
the hand.
This article has been cited by other articles:
|
|
 |
|
  E. R. Williams and S. N. Baker Renshaw Cell Recurrent Inhibition Improves Physiological Tremor by Reducing Corticomuscular Coupling at 10 Hz J. Neurosci., May 20, 2009; 29(20): 6616 - 6624. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. R. Williams and S. N. Baker Circuits Generating Corticomuscular Coherence Investigated Using a Biophysically Based Computational Model. I. Descending Systems J Neurophysiol, January 1, 2009; 101(1): 31 - 41. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Spinks, A. Kraskov, T. Brochier, M. A. Umilta, and R. N. Lemon Selectivity for Grasp in Local Field Potential and Single Neuron Activity Recorded Simultaneously from M1 and F5 in the Awake Macaque Monkey J. Neurosci., October 22, 2008; 28(43): 10961 - 10971. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. W. Boonstra, M. Roerdink, A. Daffertshofer, B. van Vugt, G. van Werven, and P. J. Beek Low-Alcohol Doses Reduce Common 10- to 15-Hz Input to Bilateral Leg Muscles During Quiet Standing J Neurophysiol, October 1, 2008; 100(4): 2158 - 2164. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Takei and K. Seki Spinomuscular Coherence in Monkeys Performing a Precision Grip Task J Neurophysiol, April 1, 2008; 99(4): 2012 - 2020. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. C. Muresan, O. F. Jurjut, V. V. Moca, W. Singer, and D. Nikolic The Oscillation Score: An Efficient Method for Estimating Oscillation Strength in Neuronal Activity J Neurophysiol, March 1, 2008; 99(3): 1333 - 1353. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. Soteropoulos and S. N. Baker Different Contributions of the Corpus Callosum and Cerebellum to Motor Coordination in Monkey J Neurophysiol, November 1, 2007; 98(5): 2962 - 2973. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. S. Yu, S. L. Kilbreath, R. C. Fitzpatrick, and S. C. Gandevia Thumb and finger forces produced by motor units in the long flexor of the human thumb J. Physiol., September 15, 2007; 583(3): 1145 - 1154. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. K. Mitchell, M. R. Baker, and S. N. Baker Muscle responses to transcranial stimulation in man depend on background oscillatory activity J. Physiol., September 1, 2007; 583(2): 567 - 579. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Raethjen, R. B. Govindan, F. Kopper, M. Muthuraman, and G. Deuschl Cortical Involvement in the Generation of Essential Tremor J Neurophysiol, May 1, 2007; 97(5): 3219 - 3228. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. Witham and S. N. Baker Network oscillations and intrinsic spiking rhythmicity do not covary in monkey sensorimotor areas J. Physiol., May 1, 2007; 580(3): 801 - 814. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Morrow, L. R. Jordan, and L. E. Miller Direct Comparison of the Task-Dependent Discharge of M1 in Hand Space and Muscle Space J Neurophysiol, February 1, 2007; 97(2): 1786 - 1798. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Davies, G. L. Gerstein, and S. N. Baker Measurement of Time-Dependent Changes in the Irregularity of Neural Spiking J Neurophysiol, August 1, 2006; 96(2): 906 - 918. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. N. Baker, M. Chiu, and E. E. Fetz Afferent Encoding of Central Oscillations in the Monkey Arm J Neurophysiol, June 1, 2006; 95(6): 3904 - 3910. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. Soteropoulos and S. N. Baker Cortico-Cerebellar Coherence During a Precision Grip Task in the Monkey J Neurophysiol, February 1, 2006; 95(2): 1194 - 1206. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. N. Christakos, N. A. Papadimitriou, and S. Erimaki Parallel Neuronal Mechanisms Underlying Physiological Force Tremor in Steady Muscle Contractions of Humans J Neurophysiol, January 1, 2006; 95(1): 53 - 66. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Gilbertson, E. Lalo, L. Doyle, V. Di Lazzaro, B. Cioni, and P. Brown Existing Motor State Is Favored at the Expense of New Movement during 13-35 Hz Oscillatory Synchrony in the Human Corticospinal System J. Neurosci., August 24, 2005; 25(34): 7771 - 7779. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. N. Riddle and S. N Baker Manipulation of peripheral neural feedback loops alters human corticomuscular coherence J. Physiol., July 15, 2005; 566(2): 625 - 639. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. T. Moritz, E. A. Christou, F. G. Meyer, and R. M. Enoka Coherence at 16-32 Hz Can Be Caused by Short-Term Synchrony of Motor Units J Neurophysiol, July 1, 2005; 94(1): 105 - 118. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Sturman, D. E. Vaillancourt, and D. M. Corcos Effects of Aging on the Regularity of Physiological Tremor J Neurophysiol, June 1, 2005; 93(6): 3064 - 3074. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Hurtado, L. L. Rubchinsky, K. A. Sigvardt, V. L. Wheelock, and C. T. E. Pappas Temporal Evolution of Oscillations and Synchrony in GPi/Muscle Pairs in Parkinson's Disease J Neurophysiol, March 1, 2005; 93(3): 1569 - 1584. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Yoshitake, M. Shinohara, M. Kouzaki, and T. Fukunaga Fluctuations in plantar flexion force are reduced after prolonged tendon vibration J Appl Physiol, December 1, 2004; 97(6): 2090 - 2097. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. Christou, J. M. Jakobi, A. Critchlow, M. Fleshner, and R. M. Enoka The 1- to 2-Hz oscillations in muscle force are exacerbated by stress, especially in older adults J Appl Physiol, July 1, 2004; 97(1): 225 - 235. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. R. Mason, L. S. Theverapperuma, C. M. Hendrix, and T. J. Ebner Monkey Hand Postural Synergies During Reach-to-Grasp in the Absence of Vision of the Hand and Object J Neurophysiol, June 1, 2004; 91(6): 2826 - 2837. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Lee Behavioral Context and Coherent Oscillations in the Supplementary Motor Area J. Neurosci., May 5, 2004; 24(18): 4453 - 4459. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Spinks, S. N. Baker, A. Jackson, P. T. Khaw, and R. N. Lemon Problem of Dural Scarring in Recording From Awake, Behaving Monkeys: A Solution Using 5-Fluorouracil J Neurophysiol, August 1, 2003; 90(2): 1324 - 1332. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
