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J Neurophysiol (April 1, 2003). 10.1152/jn.00925.2002
Submitted on Submitted 16 October 2002; accepted in final form 26 December 2002
Department of Sport and Exercise Science, University of Auckland, Auckland, New Zealand 1005
Stinear, Cathy M. and
Winston D. Byblow.
Role of Intracortical Inhibition in Selective Hand Muscle
Activation. J. Neurophysiol. 89: 2014-2020, 2003. Previous studies have shown that
intracortical inhibition (ICI) plays an important role in shaping the
output from primary motor cortex (M1). This study explored the muscle
specificity and temporal modulation of ICI during the performance of a
phasic index finger flexion task. Fifteen subjects were asked to rest their dominant hand on a computer mouse and depress the mouse button
using their index finger in time with a 1-Hz auditory metronome, while
keeping the rest of their hand as relaxed as possible. Responses to
single- and paired-pulse transcranial magnetic stimulation were
recorded from the first dorsal interosseous (FDI) and abductor pollicis
brevis (APB) muscles while subjects were at rest and during "on"
and "off" phases of the task. For FDI during the on phase,
motor evoked potential (MEP) amplitude and pretrigger EMG increased and
ICI decreased, as expected. This pattern of modulation was also
observed for APB in seven subjects. The remaining eight subjects
demonstrated a decrease in MEP amplitude and increase in ICI for APB
during the on phase. This was associated with significantly less APB
activation during the on phase. These findings suggest that an increase
in ICI and decrease in corticospinal excitability can prevent unwanted
muscle activation in a muscle-specific, temporally modulated manner.
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