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J Neurophysiol (April 1, 2003). 10.1152/jn.00582.2002
Submitted on Submitted 22 July 2002; accepted in final form 11 December 2002
Department of Neurobiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261
Temereanca, Simona and
Daniel J. Simons.
Local Field Potentials and the Encoding of Whisker Deflections by
Population Firing Synchrony in Thalamic Barreloids. J. Neurophysiol. 89: 2137-2145, 2003. In
layer IV of rat somatosensory cortex, barrel circuitry is highly
sensitive to thalamic population firing rates during the first few
milliseconds of the whisker-evoked response. This sensitivity of barrel
neurons to thalamic firing synchrony was inferred previously from
analysis of simulated barrel circuitry and from single-unit recordings
performed one at a time. In this study, we investigate stimulus-dependent synchronous activity in the thalamic ventral posteromedial nucleus (VPm) using the more direct approach of local
field potential (LFP) recording. We report that thalamic barreloid
neurons generate larger magnitude LFP responses to principal versus
adjacent whiskers, to preferred versus nonpreferred movement directions, and to high- versus low-velocity/acceleration deflections. Responses were better predicted by acceleration than velocity, and they
were insensitive to the final amplitude of whisker deflection. Importantly, reliable and robust stimulus/response relationships were
found only for the initial 1.2-7.5 ms of the thalamic LFP response,
reflecting arrival of afferent information from the brain stem. Later
components of the thalamic response, which are likely to coincide with
arrival of inhibitory inputs from the thalamic reticular nucleus and
excitatory inputs from the barrel cortex itself, are variable and
poorly predicted by stimulus parameters. Together with previous
results, these findings underscore a critical role for thalamic firing
synchrony in the encoding of small but rapidly changing perturbations
of specific whiskers in particular directions.
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