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J Neurophysiol (April 1, 2003). 10.1152/jn.00117.2002
Submitted on Submitted 12 February 2002; accepted in final form 12 December 2002
Departments of 1Ophthalmology and 2Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202
Suzuki, David A.,
Tetsuto Yamada, and
Robert
D. Yee.
Smooth-Pursuit Eye-Movement-Related Neuronal Activity in Macaque
Nucleus Reticularis Tegmenti Pontis. J. Neurophysiol. 89: 2146-2158, 2003. Neuronal responses that
were observed during smooth-pursuit eye movements were recorded from
cells in rostral portions of the nucleus reticularis tegmenti pontis
(rNRTP). The responses were categorized as smooth-pursuit eye velocity
(78%) or eye acceleration (22%). A separate population of rNRTP cells
encoded static eye position. The sensitivity to pursuit eye velocity
averaged 0.81 spikes/s per °/s, whereas the average sensitivity to
pursuit eye acceleration was 0.20 spikes/s per
°/s2. Of the eye-velocity cells with horizontal
preferences for pursuit responses, 56% were optimally responsive to
contraversive smooth-pursuit eye movements and 44% preferred
ipsiversive pursuit. For cells with vertical pursuit preferences, 61%
preferred upward pursuit and 39% preferred downward pursuit. The
direction selectivity was broad with 50% of the maximal response
amplitude observed for directions of smooth pursuit up to ±85° away
from the optimal direction. The activities of some rNRTP cells were
linearly related to eye position with an average sensitivity of 2.1 spikes/s per deg. In some cells, the magnitude of the response during
smooth-pursuit eye movements was affected by the position of the eyes
even though these cells did not encode eye position. On average,
pursuit centered to one side of screen center elicited a response that
was 73% of the response amplitude obtained with tracking centered at
screen center. For pursuit centered on the opposite side, the average response was 127% of the response obtained at screen center. The results provide a neuronal rationale for the slow, pursuit-like eye
movements evoked with rNRTP microstimulation and for the deficits in smooth-pursuit eye movements observed with ibotenic acid injection into rNRTP. More globally, the results support the notion of a frontal
and supplementary eye field-rNRTP-cerebellum pathway involved with
controlling smooth-pursuit eye movements.
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