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J Neurophysiol (May 1, 2003). 10.1152/jn.01027.2002
Submitted on Submitted 20 November 2002; accepted in final form 14 January 2003
Department of Physiology, Zhongshan Medical School of Sun Yat-sen University, 74 Zhongshan Rd 2, Guangzhou 510089, People's Republic of China
Hu, Neng-Wei,
Hong-Mei Zhang,
Xiao-Dong Hu,
Ming-Tao Li,
Tong Zhang,
Li-Jun Zhou, and
Xian-Guo Liu.
Protein Synthesis Inhibition Blocks the Late-Phase LTP of C-Fiber
Evoked Field Potentials in Rat Spinal Dorsal Horn. J. Neurophysiol. 89: 2354-2359, 2003. Previous
studies have demonstrated that in the hippocampus the maintenance of
long-term potentiation (LTP) requires de novo protein synthesis. To
investigate the role of protein synthesis in the maintenance of LTP of
C-fiber evoked field potentials in spinal dorsal horn, which may be
relevant to hyperalgesia, protein synthesis inhibitor (either
cycloheximide or anisomycin) was applied locally to the recording
segments of spinal cord in anesthetized rats, 30 min prior to tetanic
stimulation to the sciatic nerve. We found that both cycloheximide and
anisomycin selectively inhibited late-phase maintenance of the spinal
LTP but affected neither LTP induction nor baseline responses of
C-fiber evoked field potentials. In the presence of cycloheximide, LTP
of C-fiber evoked field potentials was 281.5 ± 16.5%
(n = 6) of baseline 1 h after tetanic stimulation and the potentiation significantly decreased to 235.5 ± 18.5% at 145 min after tetanic stimulation (P < 0.05). Afterward, LTP of C-fiber evoked field potentials decreased
continuously and at 270 min after tetanic stimulation reached
130.8 ± 18.0%, which was no longer different from baseline
(P > 0.05). Spinal application of anisomycin at 30 min before tetanic stimulation yielded similar results (n = 6). These results suggest that protein synthesis may be crucial for the
late-phase maintenance of LTP of C-fiber evoked field potentials in
spinal dorsal horn.
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