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J Neurophysiol (May 1, 2003). 10.1152/jn.00997.2002
Submitted on Submitted 1 November 2002; accepted in final form 13 December 2002
Vollum Institute, Oregon Health and Science University, Portland, Oregon 97201
Christie, J. M. and
G. L. Westbrook.
Regulation of Backpropagating Action Potentials in Mitral Cell
Lateral Dendrites by A-Type Potassium Currents. J. Neurophysiol. 89: 2466-2472, 2003. Dendrodendritic synapses, distributed along mitral cell lateral
dendrites, provide powerful and extensive inhibition in the olfactory
bulb. Activation of inhibition depends on effective penetration of
action potentials into dendrites. Although action potentials
backpropagate with remarkable fidelity in apical dendrites, this issue
is controversial for lateral dendrites. We used paired somatic and
dendritic recordings to measure action potentials in proximal dendritic
segments (0-200 µm from soma) and action potential-generated calcium
transients to monitor activity in distal dendritic segments (200-600
µm from soma). Somatically elicited action potentials were attenuated
in proximal lateral dendrites. The attenuation was not due to impaired
access resistance in dendrites or to basal synaptic activity. However,
a single somatically elicited action potential was sufficient to evoke a calcium transient throughout the lateral dendrite, suggesting that
action potentials reach distal dendritic compartments. Block of A-type
potassium channels (IA) with
4-aminopyridine (10 mM) prevented action potential attenuation in
direct recordings and significantly increased dendritic calcium
transients, particularly in distal dendritic compartments. Our results
suggest that IA may regulate
inhibition in the olfactory bulb by controlling action potential
amplitudes in lateral dendrites.
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